Nov 7, 2013

A filter-flow perspective of hematogenous metastasis offers a non-genetic paradigm for personalized cancer therapy

BioRxiv : the Preprint Server for Biology
Jacob G ScottPhilip Gerlee

Abstract

Translational Relevance Since the discovery of circulating tumor cells (CTC), we have struggled for ways to use them to inform treatment. The only currently accepted method for this is a ‘more is worse’ paradigm by which clinicians measure CTC burden before and after treatment to assess efficacy. Research efforts are currently focused almost entirely on genetic classification of these cells, which has yet to bear any fruit translationally. We suggest that we should shift the focus of our investigation to one driven by a physical sciences perspective. Specifically, by understanding the vascular system as a network of interconnected organs and capillary beds as filters that capture CTCs. By ascertaining the distribution of CTCs in this network for individual patients, information about the existence of subclinical metastatic disease, and therefore metastatic propensity, will come to light, and allow for better staging, prognostication and rational use of organ-directed therapy in the setting of oligometastatic disease. Purpose Research into mechanisms of hematogenous metastasis has largely become genetic in focus, attempting to understand the molecular basis of ‘seed-soil’ relationships. However, preceding this biological mechan...Continue Reading

  • References
  • Citations

References

  • We're still populating references for this paper, please check back later.
  • References
  • Citations

Citations

  • This paper may not have been cited yet.

Mentioned in this Paper

Tumor Cells, Uncertain Whether Benign or Malignant
Research
Classification
Circulatory System
Lung
Blood Flow
Organ
Evaluation
Cancer Treatment
Site

About this Paper

Related Feeds

BioRxiv & MedRxiv Preprints

BioRxiv and MedRxiv are the preprint servers for biology and health sciences respectively, operated by Cold Spring Harbor Laboratory. Here are the latest preprint articles (which are not peer-reviewed) from BioRxiv and MedRxiv.

American Thoracic Society: Clinical Problems

This feed has been developed in conjunction with the American Thoracic Society for the benefit of its Clinical Problems Assembly. It highlights new and impactful papers on clinical therapeutics, diagnoses, and practices pertaining to respiratory disease.

Related Papers

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Jacob G ScottPhilip Gerlee
Journal of Hematology & Oncology
Sai Mun LeongEvelyn S C Koay
© 2020 Meta ULC. All rights reserved