A filtered approach to neural tractography using the Watson directional function.

Medical Image Analysis
James G MalcolmYogesh Rathi

Abstract

We propose a technique to simultaneously estimate the local fiber orientations and perform multi-fiber tractography. Existing techniques estimate the local fiber orientation at each voxel independently so there is no running knowledge of confidence in the measured signal or estimated fiber orientation. Further, to overcome noise, many algorithms use a filter as a post-processing step to obtain a smooth trajectory. We formulate fiber tracking as causal estimation: at each step of tracing the fiber, the current estimate of the signal is guided by the previous. To do this, we model the signal as a discrete mixture of Watson directional functions and perform tractography within a filtering framework. Starting from a seed point, each fiber is traced to its termination using an unscented Kalman filter to simultaneously fit the signal and propagate in the most consistent direction. Despite the presence of noise and uncertainty, this provides an accurate estimate of the local structure at each point along the fiber. We choose the Watson function since it provides a compact representation of the signal parameterized by the principal diffusion direction and a scaling parameter describing anisotropy, and also allows analytic reconstructio...Continue Reading

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Citations

Jan 13, 2016·Brain Structure & Function·Demian WassermannCarl-Fredrik Westin
Nov 4, 2015·Medical Image Analysis·Maxime TaquetSimon K Warfield
Sep 10, 2014·IEEE Transactions on Medical Imaging·Guang ChengBaba C Vemuri
Apr 24, 2015·Brain Pathology·Inga K KoerteMartha E Shenton
Sep 28, 2016·Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society·Chuyang Ye, Jerry L Prince
Jul 7, 2012·Current Opinion in Neurology·Flavio Dell'Acqua, Marco Catani
May 1, 2017·International Journal of Computer Assisted Radiology and Surgery·Michael AnkeleThomas Schultz
Feb 18, 2017·Behavioral and Brain Functions : BBF·Amy K OlszewskiWendy R Kates
Jan 1, 2019·Journal of Healthcare Engineering·Zhanxiong WuDong Xu
Jul 11, 2018·NeuroImage·Dogu Baran Aydogan, Yonggang Shi

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