A Finite Element Bendo-Tensegrity Model of Eukaryotic Cell

Journal of Biomechanical Engineering
Yogesh Deepak BansodJiri Bursa

Abstract

Mechanical interaction of cell with extracellular environment affects its function. The mechanisms by which mechanical stimuli are sensed and transduced into biochemical responses are still not well understood. Considering this, two finite element (FE) bendo-tensegrity models of a cell in different states are proposed with the aim to characterize cell deformation under different mechanical loading conditions: a suspended cell model elucidating the global response of cell in tensile test simulation and an adherent cell model explicating its local response in atomic force microscopy (AFM) indentation simulation. The force-elongation curve obtained from tensile test simulation lies within the range of experimentally obtained characteristics of smooth muscle cells (SMCs) and illustrates a nonlinear increase in reaction force with cell stretching. The force-indentation curves obtained from indentation simulations lie within the range of experimentally obtained curves of embryonic stem cells (ESCs) and exhibit the influence of indentation site on the overall reaction force of cell. Simulation results have demonstrated that actin filaments (AFs) and microtubules (MTs) play a crucial role in the cell stiffness during stretching, wherea...Continue Reading

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Citations

Sep 3, 2020·International Journal of Molecular Sciences·Haibo HuangLining Sun
Sep 6, 2019·Applied Bionics and Biomechanics·Lili Wang, Weiyi Chen
Mar 9, 2021·BioMed Research International·Veera Venkata Satya Varaprasad Jakka, Jiri Bursa
Dec 12, 2020·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Kathleen T DiNapoliPablo A Iglesias
Nov 7, 2019·ACS Nano·Navid BaviKate Poole

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