Dec 27, 2014

A unified mechanism for spatiotemporal patterns in somitogenesis

BioRxiv : the Preprint Server for Biology
Yuji YasukochiKen Sahara

Abstract

Somitogenesis, the process of body segmentation during embryonic development, exhibits a key set of features that is conserved across all vertebrate species despite differences in the detailed mechanisms. Prior to the formation of somites along the pre-somitic mesoderm (PSM), periodic expression of clock genes is observed in its constituent cells. As the PSM expands through the addition of new cells at its posterior, the oscillations in the cells closer to the anterior cease and eventually lead to formation of rostral and caudal halves of the somites. This pattern formation is believed to be coordinated by interactions between neighboring cells via receptor-ligand coupling. However, the mechanism underlying the transition from synchronized oscillations to traveling waves and subsequent arrest of activity, followed by the appearance of polarized somites, has not yet been established. In this paper we have proposed a unified mechanism that reproduces the sequence of dynamical transitions observed during somitogenesis by combining the local interactions mediated via Notch-Delta intercellular coupling with global spatial heterogeneity introduced through a morphogen gradient that is known to occur along the anteroposterior axis of t...Continue Reading

  • References
  • Citations

References

  • We're still populating references for this paper, please check back later.
  • References
  • Citations

Citations

  • This paper may not have been cited yet.

Mentioned in this Paper

Fluorescent in Situ Hybridization
Chromosome Structures
Ostrinia nubilalis
Bronchioloalveolar Adenocarcinoma
Genome
Genes
Genetic Analysis
Genetic Screening Method
Corn of Toe
Moths

Related Feeds

BioRxiv & MedRxiv Preprints

BioRxiv and MedRxiv are the preprint servers for biology and health sciences respectively, operated by Cold Spring Harbor Laboratory. Here are the latest preprint articles (which are not peer-reviewed) from BioRxiv and MedRxiv.