A fish cytokine related to human IL-3, IL-5, and GM-CSF, induces development of eosinophil/basophil/mast-cell type (EBM) granulocytes.

Developmental and Comparative Immunology
Kohei NishiyaTadaaki Moritomo

Abstract

Interleukin-3 (IL-3), IL-5, and granulocyte-macrophage colony-stimulating factor (GM-CSF) are related cytokines that signal through receptors possessing the β common (βc) chain. As a family, these cytokines combine rather non-specific hematopoietic growth factor properties with a special importance for eosinophils, basophils, and mast cells. In fish the cytokines of this family are called IL-5fam, and the present study, using carp, constitutes their first functional analysis. Carp il-5fam expression was enhanced by stimulation with phytohemagglutinin and killed bacteria. Reminiscent of mammalian IL-3/IL-5/GM-CSF family members, recombinant carp IL-5fam (rcIL-5fam) induced activation of transcription factor STAT5 and efficiently promoted proliferation and colony-formation of eosinophil/basophil/mast-cell type (EBM) granulocytes. Upon addition of recombinant carp βc the growth effect of rcIL-5fam was reduced, suggesting βc participation in the signaling route. In summary, despite differences in individual cytokines and cell populations, fish and mammalian IL-3/IL-5/GM-CSF family members share growth factor functions for non-neutrophil granulocytes.

References

Dec 1, 1992·Immunology Today·A F LopezM A Vadas
Jan 1, 1987·Developmental and Comparative Immunology·J H Temmink, C J Bayne
May 23, 1995·Proceedings of the National Academy of Sciences of the United States of America·J TavernierC Oefner
Mar 15, 1994·Structure·D A RozwarskiP A Karplus
Jun 7, 1994·Proceedings of the National Academy of Sciences of the United States of America·E StanleyA R Dunn
Dec 3, 2002·Fish & Shellfish Immunology·Takamasa InoueTeruyuki Nakanishi
Dec 29, 2004·Developmental Cell·Jennifer RhodesJohn P Kanki
Aug 16, 2005·Blood·Hui-Feng LinRobert I Handin
Mar 8, 2006·Developmental and Comparative Immunology·Isao KobayashiTeruyuki Nakanishi
Apr 15, 2006·The Journal of Endocrinology·Mark O HuisingGert Flik
Oct 10, 2006·Vitamins and Hormones·James M Murphy, Ian G Young
Jul 21, 2007·BMC Evolutionary Biology·Clifford Liongue, Alister C Ward
Jun 19, 2008·Immunogenetics·Maki OhtaniJohannes Martinus Dijkstra
Jul 29, 2008·Developmental and Comparative Immunology·Ellen H StolteB M Lidy Verburg-van Kemenade
Dec 3, 2008·Developmental and Comparative Immunology·Barbara A Katzenback, Miodrag Belosevic
Jan 20, 2009·Nature Reviews. Immunology·Christopher B WilsonMasayuki Sekimata
Apr 21, 2009·Veterinary Immunology and Immunopathology·Fumihiko KatakuraTeruyuki Nakanishi
Feb 11, 2014·Developmental and Comparative Immunology·Sergey V Prykhozhij, Jason N Berman
Jul 11, 2014·Nature·Johannes M Dijkstra
Aug 19, 2014·Cellular & Molecular Immunology·Ling-Hui HsuBor-Luen Chiang
Jul 23, 2015·Immunity·Hamida Hammad, Bart N Lambrecht
Sep 13, 2015·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Michela GuarientiMaurizio Memo
Jan 15, 2016·Fish & Shellfish Immunology·Takuya YamaguchiTadaaki Moritomo
Aug 6, 2016·Developmental and Comparative Immunology·Takuya YamaguchiJohannes M Dijkstra
Aug 6, 2016·Cell Stem Cell·Roy Drissen, Claus Nerlov
May 16, 2018·Proceedings of the National Academy of Sciences of the United States of America·Lily C HughesQiong Shi
Aug 24, 2018·Molecular Medicine·Monowar AzizPing Wang
Apr 18, 2019·Immunity·Michael DouganStephanie K Dougan
May 28, 2019·Science Immunology·Roy DrissenClaus Nerlov

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basophils

Basophils are myeloid cells with a high affinity IgE receptor and is involved in inflammatory responses during allergy. Discover the latest research on Basophils here.