PMID: 9527643Apr 4, 1998Paper

A fish oil-derived concentrate enriched in eicosapentaenoic and docosahexaenoic acid as ethyl esters inhibits the formation and growth of aberrant crypt foci in rat colon

Pharmacology & Toxicology
J E PaulsenJ Alexander

Abstract

It was examined whether the fish oil derived n-3 fatty acid concentrate K85 (51.0% of eicosapentaenoic acid, 35.3% of docosahexaenoic acid and 7.7% of other n-3 fatty acids, all as ethyl esters) could inhibit the initial formation of aberrant crypt foci and the later growth of pre-existing aberrant crypt foci in the colon of male F344 rats treated with the carcinogens dimethylhydrazine or azoxymethane, the proximate metabolite of dimethylhydrazine. Given intragastrically 5 times a week, K85 caused a dose-dependent reduction of the initial (week 0-6) formation of aberrant crypt foci induced by azoxymethane (2 x 15 mg/kg body weight/injection the first two weeks). The number of aberrant crypt foci was reduced by 36% (P < 0.001) with 3.0 g K85/kg body weight/dose, the largest dose tested. The reduction was most pronounced (46%, P = 0.009) among the fastest growing aberrant crypt foci (foci with 3 or more aberrant crypts). When given in a later phase of the carcinogenesis (week 17-23) a similar intragastric treatment with K85 caused a dose-dependent reduction of the growth of pre-existing aberrant crypt foci induced by dimethylhydrazine (3 x 20 mg/kg body weight/injection the first week). The crypt multiplicity (aberrant crypt/focu...Continue Reading

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Citations

Sep 13, 2007·Cancer Metastasis Reviews·Yong Q ChenIsabelle M Berquin
Mar 18, 2000·Toxicology Letters·J Alexander
Sep 5, 2008·PPAR Research·Iris J Edwards, Joseph T O'Flaherty
Oct 27, 2004·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·P BunpoY Ohnishi
Jun 21, 2011·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Nicolaas E P DeutzRobert R Wolfe
Jan 13, 2011·JPEN. Journal of Parenteral and Enteral Nutrition·Hongyu XueVickie E Baracos
Jun 18, 2005·American Journal of Respiratory Cell and Molecular Biology·Aziz HichamiNaim A Khan
Aug 24, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·P Bougnoux

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