A Five-MicroRNA Signature Predicts Survival and Disease Control of Patients with Head and Neck Cancer Negative for HPV Infection

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Julia HessClaus Belka

Abstract

Human papillomavirus (HPV)-negative head and neck squamous cell carcinoma (HNSCC) is associated with unfavorable prognosis, while independent prognostic markers remain to be defined. We retrospectively performed miRNA expression profiling. Patients were operated for locally advanced HPV-negative HNSCC and had received radiochemotherapy in eight different hospitals (DKTK-ROG; n = 85). Selection fulfilled comparable demographic, treatment, and follow-up characteristics. Findings were validated in an independent single-center patient sample (LMU-KKG; n = 77). A prognostic miRNA signature was developed for freedom from recurrence and tested for other endpoints. Recursive-partitioning analysis was performed on the miRNA signature, tumor and nodal stage, and extracapsular nodal spread. Technical validation used qRT-PCR. An miRNA-mRNA target network was generated and analyzed. For DKTK-ROG and LMU-KKG patients, the median follow-up was 5.1 and 5.3 years, and the 5-year freedom from recurrence rate was 63.5% and 75.3%, respectively. A five-miRNA signature (hsa-let-7g-3p, hsa-miR-6508-5p, hsa-miR-210-5p, hsa-miR-4306, and hsa-miR-7161-3p) predicted freedom from recurrence in DKTK-ROG [hazard ratio (HR) 4.42; 95% confidence interval (CI)...Continue Reading

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Citations

Apr 29, 2020·Journal of Cellular Physiology·Xinyuan Zhao, Li Cui
Jan 29, 2020·Cancers of the Head & Neck·Mara S SerafiniCarlo Resteghini
May 28, 2020·International Journal of Molecular Sciences·Takashi TakeuchiSilvia Zappavigna
Oct 18, 2019·Frontiers in Oncology·Cheng XiaoNong Xu
Nov 17, 2020·Frontiers in Oncology·Wei HuangMing-Xiang Zou
Nov 11, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·David A ClumpHeath D Skinner
Feb 2, 2021·Frontiers in Cell and Developmental Biology·Spyridon GougousisIoannis Constantinidis
Apr 10, 2020·Cancer Letters·Antoine GalmicheFlorian Clatot
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Aug 3, 2021·Frontiers in Big Data·Hamid Reza Hassanzadeh, May D Wang
Nov 28, 2021·Molecular Biology Reports·Sethu Thakachy SubhaHasni Idayu Saidi

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