A five-miRNA signature with prognostic and predictive value for MGMT promoter-methylated glioblastoma patients

Oncotarget
Wen ChengAnhua Wu

Abstract

Although O(6)-methylguanine DNA methyltransferase (MGMT) promoter methylation status is an important marker for glioblastoma multiforme (GBM), there is considerable variability in the clinical outcome of patients with similar methylation profiles. The present study aimed to refine the prognostic and predictive value of MGMT promoter status in GBM by identifying a micro (mi)RNA risk signature. Data from The Cancer Genome Atlas was used for this study, with MGMT promoter-methylated samples randomly divided into training and internal validation sets. Data from The Chinese Glioma Genome Atlas was used for independent validation. A five miRNA-based risk signature was established for MGMT promoter-methylated GBM to distinguish cases as high- or low-risk with distinct prognoses, which was confirmed using internal and external validation sets. Importantly, the prognostic value of the signature was significant in different cohorts stratified by clinicopathologic factors and alkylating chemotherapy, and a multivariate Cox analysis found it to be an independent prognostic marker along with age and chemotherapy. Based on these three factors, we developed a quantitative model with greater accuracy for predicting the 1-year survival of patie...Continue Reading

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Citations

Jan 5, 2018·Journal of Cancer Research and Clinical Oncology·Ruichao ChaiJing Chen
Dec 24, 2018·Journal of Applied Toxicology : JAT·Haoyu HuangDalin Hu
Apr 15, 2017·BioMed Research International·Chengqi Sun, Xudong Zhao
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Jan 7, 2019·BMC Dermatology·Mariya AksenenkoTatiana Ruksha
Mar 6, 2021·Frontiers in Molecular Biosciences·Xiaomeng LiShuo Xu
Aug 17, 2021·Journal of Oncology·Xisong LiangZhixiong Liu

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Methods Mentioned

BETA
surgical resection

Software Mentioned

SPSS
GraphPad Prism

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