A five-year itch in TNF-alpha cytotoxicity: the time factor determines JNK action

Developmental Cell
Anning Lin

Abstract

The intricate interplay between NF-kappaB and JNK determines TNF-alpha cytotoxicity. In a recent Cell paper, report that prolonged JNK1 activation promotes TNF-alpha killing via E3 ligase-mediated degradation of the caspase 8 inhibitor cFLIP(L). On the other hand, Ventura et al. (2006) show in their recent Molecular Cell paper that transient JNK activation suppresses TNF-alpha-induced cell death.

References

Jan 1, 2003·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Anning Lin
Jun 25, 2003·Molecular Cell·Jennifer A LambRoger J Davis
Mar 2, 2006·Molecular Cell·Juan-Jose VenturaRoger J Davis

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Citations

Sep 8, 2010·The Journal of Biological Chemistry·Christine SalaünGérard Friedlander
May 13, 2008·The Journal of Biological Chemistry·Hongbin DengAnning Lin
Feb 17, 2007·Current Opinion in Cell Biology·Claire R Weston, Roger J Davis
Jun 24, 2008·Cancer Letters·Jennifer L TaylorCarrie W Rinker-Schaeffer
Jan 30, 2020·Journal of Enzyme Inhibition and Medicinal Chemistry·Qinghua WuKamil Kuca
Jul 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gautam SethiBharat B Aggarwal
Nov 13, 2012·Structure·John D LaughlinPhilip V LoGrasso

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