A five-year retrospective analysis of adherence in cystic fibrosis

Pediatric Pulmonology
Aarti ShakkottaiSamya Z Nasr

Abstract

We conducted a retrospective analysis of medication adherence and health outcomes over a 5-year period in children with cystic fibrosis (CF). Adherence was calculated for several commonly prescribed CF medications by comparing the actual number of times a prescription was filled in a 12-month period to the number of times it should have been filled based on the prescribed supply. We used prescription refill histories as documented by three major specialty pharmacies used by our patients. A binomial mixed effects model was used to investigate the longitudinal association between adherence and age group (0-5, 6-12, and 13-21 years) with gender, year in the study, lung function, body mass index (BMI), and annual hospitalization rate included as potential confounders. The 0-5 years group had the highest overall adherence (P = 0.009). The 6-12 years group had significantly better adherence to inhaled medications as compared to oral medications (P = 0.020). Within each group, for any given year in the study, having a higher BMI was associated with greater odds of adherence (P < 0.0001). There were no associations between adherence and gender, lung function or hospitalization rate (P > 0.05). There are significant age differences in a...Continue Reading

References

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Citations

May 14, 2016·Pediatric Pulmonology·Adrienne P Savant, Susanna A McColley
Jan 22, 2017·Expert Review of Respiratory Medicine·Siva NarayananDaniel Grossoehme
Feb 20, 2018·Pediatric Pulmonology·Aarti ShakkottaiSamya Z Nasr
Mar 8, 2018·Pediatric Pulmonology·Heather S KirkhamGregory S Sawicki
Jul 7, 2018·Pediatric Pulmonology·Emily F MutherGreg S Sawicki
Mar 19, 2019·Pediatric Pulmonology·Kevin W SouthernSarath Ranganathan
Aug 7, 2017·Global Pediatric Health·Beverly FitzPatrickTiffany Lee
Feb 24, 2017·Global Pediatric Health·Aarti Shakkottai, Samya Z Nasr
Nov 30, 2019·Ciência & saúde coletiva·Danielle Portella FerreiraAna Carolina Carioca da Costa
Jun 11, 2020·Revista paulista de pediatria : orgão oficial da Sociedade de Pediatria de São Paulo·Bianca Sampaio BonfimEdna Lúcia Souza
Apr 14, 2017·Italian Journal of Pediatrics·Marco MaglioneFrancesca Santamaria
Mar 11, 2020·Frontiers in Pharmacology·Miquéias Lopes-Pacheco
Jan 7, 2020·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Lucie OlivereauQuitterie Reynaud
Jul 29, 2021·BMC Pediatrics·Qionghua ChenShunying Zhao

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