A fixed combination of cinnarizine/dimenhydrinate for the treatment of patients with acute vertigo due to vestibular disorders : a randomized, reference-controlled clinical study.

Clinical Drug Investigation
Ales HahnWolfgang Baumann

Abstract

Vestibular dysfunction commonly leads to - often severe - vertigo symptoms. The objective of this study was to compare the antivertiginous efficacy and tolerability of a fixed combination of cinnarizine/dimenhydrinate with those of betahistine in patients with acute vertigo due to vestibular disorders. Sixty-six patients experiencing acute vertigo attacks participated in this prospective, double-blind, three-centre, comparative study. Patients who assessed at least one vertigo symptom as being of medium intensity (> or =2) on a 5-point visual analogue scale (VAS; from 0 = no symptoms to 4 = very severe symptoms) were randomly allocated to treatment with the fixed combination of cinnarizine 20 mg and dimenhydrinate 40 mg three times daily or betahistine 12 mg three times daily for 4 weeks. The primary efficacy endpoint was change in mean vertigo score, as determined by patients' assessments of 12 individual vertigo symptoms on the 5-point VAS after 4 weeks of treatment. Treatment with the fixed combination led to significantly greater improvements in mean vertigo scores than the reference therapy betahistine after 4 weeks of therapy (p = 0.013). The differences were clinically relevant, based on the Mann-Whitney estimator. Furth...Continue Reading

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Citations

Mar 24, 2011·Climacteric : the Journal of the International Menopause Society·P Y CezarinoE C Baracat
Dec 15, 2015·Wiener klinische Wochenschrift·Arne-Wulf ScholtzGerhard Weisshaar
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Dec 29, 2020·The American Journal of Emergency Medicine·Dogan ErcinDilek Ozge Zincir Ercin
Jun 24, 2021·Drugs & Aging·Augusto Pietro CasaniSilvia Capobianco

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