PMID: 8964131Mar 1, 1996Paper

A flow model of respiration in health and disease

Clinical Physiology
O Nisell

Abstract

Respiratory functions operating to transport O2 are depicted by a flow diagram which consists of eight consecutive units, each depending on the preceding one. All the units are characterized by three features: applicable drive, special capability and outgoing flow. The flows are: respiratory centre output for breathing; effects of respiratory motor nerves; contractions of respiratory muscles; ventilation movements of abdomen and thorax wall; ventilation movements of lungs and air; O2 taken up during ventilation transport; O2 flow through alveolar membrane; and O2 consumed during blood transport. Equations describe connections of the units. The magnitude of the pleural pressure swing during the ventilation cycle apparently estimates the respiratory drive if the functional connection from the respiratory centre to pleural pressure is normal. Data from the literature are used to evaluate some unit parameters, at rest and during exercise. Breathlessness in somatic disease appears to originate from a low special capability of one or several units, raising, as does exercise, respiratory drive and effort.

References

Oct 1, 1975·Journal of Applied Physiology·F L Eldridge
Jan 1, 1992·Clinical Physiology·O Nisell
Jun 1, 1992·The American Review of Respiratory Disease·O TaguchiT Takishima
Oct 1, 1991·The Journal of Physiology·M C KearonK J Killian
Nov 1, 1990·The American Review of Respiratory Disease·P M SimonS E Weinberger
Mar 1, 1990·Clinical Physiology·K Borg, L Kaijser
May 1, 1989·The American Review of Respiratory Disease·R M SchwartzsteinS E Weinberger
Jul 1, 1986·Journal of Applied Physiology·P D WagnerH A Saltzman
Apr 1, 1988·The American Review of Respiratory Disease·A Mier-JedrzejowiczM Green
Sep 1, 1986·Journal of Applied Physiology·A el-ManshawiN L Jones
Aug 1, 1985·Chest·M D Altose
Jan 1, 1986·The American Review of Respiratory Disease·S T Weiss
Aug 1, 1972·Journal of Applied Physiology·B EkblomB Gullbring
Mar 1, 1966·Journal of Applied Physiology·R V LourençoA P Fishman
Sep 1, 1984·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·K J KillianE J Campbell
Oct 1, 1982·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·J G BurdonE J Campbell
Jan 1, 1956·Journal of Applied Physiology·A B OTISE P RADFORD
Jan 1, 1958·The Journal of Clinical Investigation·J T SHARPD G GREENE
Jan 1, 1960·Journal of Applied Physiology·J V AUDITOREJ M FLEXNER
Jan 1, 1962·Acta Allergologica·E HELANDERH WESTLING
Sep 1, 1963·Acta Physiologica Scandinavica·O NISELL
May 1, 1965·Annals of Internal Medicine·N R ANTHONISEN, H J SMITH
Feb 17, 1960·Acta Medica Scandinavica·O NISELL
Aug 1, 1962·Proceedings of the Society for Experimental Biology and Medicine·R L KATZ NGAISH

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