A Fluorescent Switch Sensor for Glutathione Detection Based on Mn-doped CdTe Quantum Dots - Methyl Viologen Nanohybrids

Journal of Fluorescence
Lurong YuYaxiang Lu

Abstract

In the work, a fluorescence switch sensor consists of Mn-doped CdTe quantum dots (QDs) - methyl viologen (MV(2+)) nanohybrid is fabricated. In the sensor, MV(2+) plays a role in turning the QDs fluorescence to the "OFF" state due to the efficient electron transfer process while glutathione (GSH) could turn "ON" the native QDs fluorescence by effectively releasing QDs from the QDs-MV(2+) nanohybrids. In addition, the recovery level of QDs fluorescence is closely related to the amount of GSH. Based on this phenomenon, a reliable and convenient GSH quantitative determination method is established, which not only has a wide determination range of 1.2-200 μM, a low detection limit of 0.06 μM and a short detection time but also can realize the selective detection of GSH upon other competitive biothiols (homocysteine and cysteine) that are coexistent in biological systems. The developed sensor will greatly benefit to the study of GSH amount, helping the understanding of its function in biological systems.

References

Feb 22, 2007·Journal of the American Chemical Society·Narayan Pradhan, Xiaogang Peng
Jul 8, 2008·Molecular Aspects of Medicine·Shelly C Lu
Feb 5, 2009·Journal of the American Chemical Society·Victor V MatylitskyJosef Wachtveitl
Apr 14, 2010·Chemical Communications : Chem Comm·Jiaofang LiuLinyong Zhu
Jan 1, 2008·Environmental Toxicology and Pharmacology·Gülüzar Atli, Mustafa Canli
Nov 24, 2011·Journal of the American Chemical Society·Renren DengXiaogang Liu
May 18, 2013·Luminescence : the Journal of Biological and Chemical Luminescence·Wei BianShaomin Shuang
May 21, 2013·Organic & Biomolecular Chemistry·Xiao-Dong LiuJian-Mei Lu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.