A focused 35-minute whole body MRI screening protocol for patients with von Hippel-Lindau disease

Hereditary Cancer in Clinical Practice
Anne-Marie VanbinstSven Gläsker

Abstract

Von Hippel-Lindau (VHL) disease is an autosomal dominantly inherited tumor syndrome. Affected patients develop central nervous system hemangioblastomas and abdominal tumors, among other lesions. Patients undergo an annual clinical screening program including separate magnetic resonance imaging (MRI) of the brain, whole spine and abdomen. Consequently, patients are repeatedly subjected to time-consuming and expensive MRI scans, performed with cumulative Gadolinium injections. We report our experience with a 35-min whole body MRI screening protocol, specifically designed for detection of VHL-associated lesions. We designed an MRI protocol dedicated to the typical characteristics of VHL-associated lesions in different imaging sequences, within the time frame of 35 min. Blank imaging of the abdomen is carried out first, followed by abdominal sequences with Gadolinium contrast. Next, the full spine is examined, followed by imaging of the brain. A single dose of contrast used for abdominal imaging is sufficient for further highlighting of spine- and brain lesions, thus limiting the Gadolinium dosage. We used 1.5 Tesla equipment, dealing with fewer artifacts compared to a 3 Tesla system for spine- and abdominal imaging, while preservi...Continue Reading

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Citations

Jul 2, 2020·OncoTargets and Therapy·Sven GläskerAlexander O Vortmeyer
Dec 12, 2020·Seminars in Musculoskeletal Radiology·Amanda IsaacAnwar R Padhani
Apr 2, 2021·Pediatric Radiology·Haifa Al-SarhaniMary-Louise C Greer

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