A focused review of myokines as a potential contributor to muscle hypertrophy from resistance-based exercise.

European Journal of Applied Physiology
Stephen M CornishJudy E Anderson

Abstract

Resistance exercise induces muscle growth and is an important treatment for age-related losses in muscle mass and strength. Myokines are hypothesized as a signal conveying physiological information to skeletal muscle, possibly to "fine-tune" other regulatory pathways. While myokines are released from skeletal muscle following contraction, their role in increasing muscle mass and strength in response to resistance exercise or training is not established. Recent research identified both local and systemic release of myokines after an acute bout of resistance exercise. However, it is not known whether myokines with putative anabolic function are mechanistically involved in producing muscle hypertrophy after resistance exercise. Further, nitric oxide (NO), an important mediator of muscle stem cell activation, upregulates the expression of certain myokine genes in skeletal muscle. In the systemic context of complex hypertrophic signaling, this review: (1) summarizes literature on several well-recognized, representative myokines with anabolic potential; (2) explores the potential mechanistic role of myokines in skeletal muscle hypertrophy; and (3) identifies future research required to advance our understanding of myokine anabolism s...Continue Reading

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Citations

Mar 24, 2021·The FEBS Journal·Michael Attwaters, Simon M Hughes
Jun 11, 2021·The American Journal of Sports Medicine·Bradley LambertPatrick McCulloch
Aug 28, 2021·International Journal of Molecular Sciences·Rosa MancinelliGiorgio Fanò-Illic

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