PMID: 9431569Feb 7, 1998Paper

A follow-up study of environmental and biologic determinants of fertility among 430 Danish first-pregnancy planners: design and methods

Reproductive Toxicology
J P BondeJ Olsen

Abstract

This paper presents design and methods of a follow-up study of fecundability (defined as the probability of conception during one menstrual cycle) in first-pregnancy planners. We recruited 430 couples by postal letter among 52,255 members of four trade unions. Couples without earlier reproductive experience were enrolled when they discontinued contraception and were followed in six complete menstrual cycles or until a pregnancy was recognized. Data included daily recordings of coitus and menstrual bleeding. Blood, semen, and urine specimens were collected to assess endocrine profile, semen quality, occult embryonal loss, and occupational exposures. Information was obtained about 1661 menstrual cycles (94% of expected). The proportion of couples obtaining a clinical pregnancy during 6 months of follow-up was 65%, and the average probability to obtain a pregnancy across all cycles was 16% (95% CI 14-18%). Among all conceptions the proportion of early embryonal loss was 17% (95% CI 12-22%). This study demonstrates the feasibility of a prospective study of fertility and that the established study base can provide useful information on environmental risk to subfertility.

References

Oct 1, 1992·The New England Journal of Medicine·A S RowlandA J Wilcox
Dec 1, 1992·International Journal of Epidemiology·G A ZielhuisE I Florack
Sep 1, 1989·Journal of Epidemiology and Community Health·M Joffe
Dec 1, 1988·The New England Journal of Medicine·I Hertz-Picciotto, S J Samuels
Jun 1, 1994·Journal of Psychosomatic Obstetrics and Gynaecology·H VartiainenR Rimón

❮ Previous
Next ❯

Citations

Feb 12, 2010·European Journal of Epidemiology·Krista F HuybrechtsKenneth J Rothman
Jul 31, 1999·Fertility and Sterility·N H HjollundJ Olsen
Feb 7, 1998·Reproductive Toxicology·N H HjollundJ Olsen
Apr 16, 1998·Reproductive Toxicology·N H HjollundJ Olsen
Jul 25, 2000·International Journal of Andrology·J OlsenA Abell
Sep 30, 2000·International Journal of Andrology·N H HjollundJ Olsen
Sep 11, 2008·International Journal of Epidemiology·Ellen M MikkelsenHenrik Toft Sørensen
Nov 25, 2011·Environmental Health Perspectives·Gunnar ToftJens Peter Bonde
Dec 31, 2003·Environmental Health Perspectives·Germaine M BuckSteven M Schrader
Dec 31, 2003·Environmental Health Perspectives·Candace TingenDavid B Dunson
Dec 7, 2013·Reproduction : the Official Journal of the Society for the Study of Fertility·Germaine M Buck Louis
Oct 3, 2014·Reproductive Health·Sunni L MumfordJosé M Belizán
Mar 31, 2009·Fertility and Sterility·Joseph B StanfordSara E Simonsen
Jan 14, 2004·International Journal of Andrology·Julie StøyJens Peter Bonde
Sep 13, 2012·Statistics in Medicine·Germaine M Buck Louis, Rajeshwari Sundaram
Jun 10, 2016·Environmental Health : a Global Access Science Source·Christina A PorucznikJoseph B Stanford
Jul 15, 2016·Human Reproduction·Melissa M SmarrGermaine M Buck Louis
Aug 2, 2003·Revista do Hospital das Clínicas·Fábio Firmbach PasqualottoSami Arap
Jan 9, 2004·Epidemiology·Niels Henrik I HjollundUNKNOWN Danish First Pregnancy Planner Study Team
Jan 9, 2004·Epidemiology·Niels Henrik I HjollundUNKNOWN Danish First Pregnancy Planner Study Team
Oct 30, 2016·Andrology·C J PatelG M Buck Louis
Sep 11, 2018·Epidemiology·Marianthi-Anna KioumourtzoglouMarc G Weisskopf
Jun 7, 2006·Epidemiology·Rémy SlamaJean Bouyer
Jun 14, 2005·Epidemiology·Markku SallménAllen J Wilcox
Jan 30, 2008·Basic & Clinical Pharmacology & Toxicology·Sylvaine Cordier
Jun 11, 2019·Epidemiology·Wenting ZhuUNKNOWN Shanghai Birth Cohort Study
May 3, 2013·PloS One·Espen Jimenez-SolemHenrik Enghusen Poulsen
Jun 22, 2019·Maternal and Child Health Journal·Marleen M H J van GelderNel Roeleveld
Oct 19, 2004·Human Reproduction·G M Buck LouisL A Schieve
May 28, 2005·Human Reproduction·M S JensenJ P Bonde
Apr 17, 2020·Human Reproduction·Allen J WilcoxEli Y Adashi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.