A follow up study of suicide attempters: increase of CSF-somatostatin but no change in CSF-CRH

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
A WestrinLil Träskman-Bendz

Abstract

Concentrations of somatostatin and corticotrophin releasing hormone (CRH), measured in cerebrospinal fluid (CSF) have been reported to be low in suicidal patients with major depressive disorder (MDD). Often have MDD patients in general, high CSF-CRH and low CSF-somatostatin concentrations, which both seem to normalise with clinical recovery. The present study was designed to look for CSF-CRH and CSF-somatostatin alterations along with clinical changes in patients studied repeatedly after a suicide attempt. Sixteen patients with different diagnoses, initially inpatients after a suicide attempt (baseline), participated. Lumbar punctures and ratings according to the Suicidal Assessment Scale (SUAS) and the Montgomery-Asberg Depression Rating Scale (MADRS) were performed while patients were drug-free (baseline) and after a median of 7 (5 to 9) months. At follow up MADRS- and SUAS-scores were significantly decreased (P<0.05), whereas CSF-somatostatin was significantly increased (P=0.013) and CSF-CRH had not changed significantly. Thus, the patients showed long-lasting low CSF-CRH concentrations, in spite of changed CSF-somatostatin concentrations and clinical amelioration.

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Citations

Feb 23, 2010·European Archives of Psychiatry and Clinical Neuroscience·Maurizio PompiliDavid Lester
Dec 14, 2004·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Annica OlssonAsa Westrin
May 20, 2003·Neurotoxicity Research·David De Wied, Hein O. Sigling
Aug 30, 2013·BioMed Research International·Gianluca SerafiniPaolo Girardi
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Aug 2, 2008·Psychoneuroendocrinology·Daniel LindqvistLena Brundin
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Apr 18, 2012·Journal of Preventive Medicine and Public Health = Yebang Ŭihakhoe Chi·Kyu-Seok CheongIn-Kyung Hwang
Jun 6, 2021·Psychoneuroendocrinology·Johannes M HenningsSusanne Lucae

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