Abstract
Oxidative stress has been implicated in cardiac remodeling (cardiac fibrosis and hypertrophy), which impairs cardiac function and metabolism; therefore, it is anticipated antioxidative compounds will have protective properties against cardiac remodeling. Luteolin (3',4',5,7-tetrahydroxyflavone), a widely distributed flavonoid found in many herbal extracts including celery, green pepper, perilla leaves and seeds, and chamomile, is a known to be a potent antioxidant and was previously demonstrated to exert an antifibrotic effect in the lungs and the liver. In this study, we clearly demonstrate that oral pretreatment with the higher-luteolin diet (0.035% (wt/wt)) protected against cardiac fibrosis and hypertrophy as well as a hyperoxidative state in Ang II-infused rats. In cardiac tissue, increased gene expression levels of TGFβ1, CTGF, Nox2, Nox4, ANP, and BNP induced by Ang II were restored by oral pretreatment of this high-luteolin diet. In cultured rat cardiac fibroblasts, H2O2-induced TGFβ1 expression and the phosphorylation of JNK were suppressed by luteolin pretreatment. In conclusion, food-derived luteolin has protective actions against Ang II-induced cardiac remodeling, which could be mediated through attenuation of oxida...Continue Reading
References
Nov 25, 1998·FEBS Letters·K ShimoiN Kinae
Sep 20, 2000·Circulation·C G BrillaH Rupp
Nov 30, 2000·Circulation·F ZannadB Pitt
Feb 15, 2001·Circulation·D S LimA J Marian
Oct 5, 2001·Journal of the American College of Cardiology·C M YuC P Lau
Oct 13, 2001·Circulation Research·M SanoS Ogawa
Nov 13, 2001·Current Opinion in Cardiology·J DíezR Querejeta
Jan 24, 2002·Circulation·Jennifer K BendallAjay M Shah
May 30, 2002·Circulation·Javier DíezJosé L Martínez Ubago
May 30, 2002·Circulation·Ying Tung SiaJean L Rouleau
Oct 5, 2002·Hypertension·Jian-Mei LiAjay M Shah
Dec 14, 2002·Circulation Research·Ichiro ManabeRyozo Nagai
Dec 31, 2002·Journal of Molecular and Cellular Cardiology·Claude Delcayre, Bernard Swynghedauw
Dec 4, 2003·Journal of the American College of Cardiology·Tzu-Hurng ChengJin-Jer Chen
Feb 18, 2004·Hypertension·Fumitaka KuwaharaTsutomu Imaizumi
May 1, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Andrew Leask, David J Abraham
Jul 28, 2004·Cardiovascular Research·Stephan Rosenkranz
Dec 29, 2004·Cardiovascular Research·Patrizia CamellitiPeter Kohl
May 4, 2005·Circulation·Hideshi OkadaHisayoshi Fujiwara
Feb 21, 2006·Journal of the American College of Cardiology·Ali J MarianRaffaella Lombardi
Jun 21, 2006·Circulation·Alice H LichtensteinJudith Wylie-Rosett
Dec 28, 2006·Hypertension·Eiki Takimoto, David A Kass
Jan 18, 2007·Journal of Agricultural and Food Chemistry·Ting ChenSu Zeng
May 10, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Danijel JuricThomas Netticadan
Jul 3, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Indroneal BanerjeeTroy A Baudino
Jul 10, 2007·The Journal of Clinical Hypertension·Javier Díez
Feb 23, 2008·The Journal of Clinical Investigation·Tatsuya MorimotoKoji Hasegawa
Jul 3, 2008·Journal of Agricultural and Food Chemistry·O Benavente-García, J Castillo
Jan 7, 2009·Therapeutic Advances in Cardiovascular Disease·Christian M Werner, Michael Böhm
Mar 4, 2009·Circulation·Raffaella LombardiAli J Marian
Mar 18, 2009·Circulation·Vernon W DolinskyJason R B Dyck
Sep 15, 2009·Toxicology and Applied Pharmacology·Robert DomitrovićIvana Sain
Oct 27, 2009·FEBS Letters·Chieko AndoTeruo Kawada
Dec 5, 2009·Circulation Research·Colby A SoudersTroy A Baudino
Jul 28, 2010·Hypertension·Yuka Sumitomo-UedaToshio Matsumoto
Sep 3, 2010·The Journal of Clinical Investigation·Polakit TeekakirikulJonathan G Seidman
Oct 21, 2010·Journal of Agricultural and Food Chemistry·Chiu-Yuan ChenShih-Lan Hsu
Dec 24, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Pei-Hu LiaoShiang-Suo Huang
Apr 19, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Peng ZhangUlrike Mende
Jun 16, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Tetsuro AgoTakanari Kitazono
Feb 22, 2012·Clinical and Experimental Pharmacology & Physiology·Wei ZhangWeizhong Zhu
Mar 6, 2012·Circulation·Fuzhong QinWilson S Colucci
Citations
Dec 17, 2016·Molecular Nutrition & Food Research·Luis D GodoyBradley S Ferguson
Mar 3, 2018·Frontiers in Pharmacology·Ning ZhangQi-Zhu Tang
Oct 24, 2017·Frontiers in Pharmacology·Yuanyuan LuoDongye Li
Oct 24, 2018·Heart Failure Reviews·Brahmanaidu ParimGanapathy Saravanan
Jan 21, 2021·Molecular and Cellular Biochemistry·Henrique Charlanti Reis AssunçãoLiliam Fernandes
Dec 7, 2019·Phytochemistry·M MicucciA Angeletti
Mar 25, 2021·ChemMedChem·Richa SharmaNiti Kumar
Jul 25, 2021·Bioorganic Chemistry·Bo LiangNing Gu