PMID: 2498162Mar 1, 1989Paper

A FOS protein is present in a complex that binds a negative regulator of MYC

Genes & Development
N HayJ M Bishop

Abstract

Regulation of the human proto-oncogene MYC apparently plays an important role in cellular proliferation and the genesis of diverse tumors. Transcription from MYC is governed principally by two promoters known as P1 and P2. Previously we have detected a negative regulator of these promoters upstream of MYC. We now report that this regulator comprises no more than 26 bp of DNA, with sequence that resembles the regulators of at least two other genes, and we describe nuclear factors that interact with the regulator. Nuclear extracts from human cells form three distinctive complexes with the negative regulator. One of these complexes includes the product of the proto-oncogene FOS or an antigenically related protein, and the FOS protein may, in turn, be associated with the product of the proto-oncogene JUN. Similarly, FOS and JUN proteins produced by translation in vitro bind cooperatively to the negative regulator. These results raise the possibility that FOS and JUN participate in the regulation of MYC.

References

Aug 18, 1988·Nature·W W LamphI M Verma
Jul 28, 1988·Nature·P Sassone-CorsiI M Verma
Jan 1, 1986·Annual Review of Genetics·M D Cole
May 20, 1988·Science·F J RauscherB R Franza
Sep 1, 1987·Genes & Development·N HayD Levens
Sep 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·R G RamsayP A Marks
Apr 1, 1973·Virology·F L Graham, A J van der Eb
Dec 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·G RamsayJ M Bishop
Jan 1, 1983·Methods in Enzymology·J D DignamR G Roeder

❮ Previous
Next ❯

Citations

Mar 1, 1990·Journal of Cellular Biochemistry·K Saksela
Sep 1, 1992·Journal of Cellular Biochemistry·A Kimchi
Mar 1, 1994·Journal of Cellular Biochemistry·H LinA Shirley-Henderson
Jan 1, 1990·Immunologic Research·B M PeterlinS Tsang
Jan 1, 1993·Pharmacology & Therapeutics·M R SmithH F Kung
Jan 1, 1992·Brain Research. Molecular Brain Research·M A McCormackG D Mower
Feb 1, 1996·The International Journal of Biochemistry & Cell Biology·R BhatE Bresnick
Jul 3, 1999·Diabetic Medicine : a Journal of the British Diabetic Association·B KennonJ M Connell
Nov 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·Y Yamaguchi-IwaiY Ito
Oct 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·D H Mack, L A Laimins
Feb 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·G BarrettV J Dzau
May 24, 1994·Proceedings of the National Academy of Sciences of the United States of America·A Brys, N Maizels
Apr 11, 1992·DNA and Cell Biology·W E HortonR Balakir
Jun 11, 1991·Nucleic Acids Research·E Principaud, G Spohr
May 31, 2001·Microbiology and Molecular Biology Reviews : MMBR·K A Gottlieb, L P Villarreal
Apr 1, 1995·The Journal of Clinical Investigation·D A Albert
Nov 24, 2007·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·B Kennon, J M Connell
Jul 13, 2000·Proceedings of the National Academy of Sciences of the United States of America·K TamuraV J Dzau
Jan 30, 2016·Nucleic Acids Research·Elisa N SalasIstvan Ladunga
Jan 1, 1991·Annals of the New York Academy of Sciences·R Z FlorkiewiczN Shah
Sep 1, 1996·Kidney International·H YoshidaI Ichikawa
Dec 1, 1991·Baillière's Clinical Endocrinology and Metabolism·J E DumontP P Roger
Jul 26, 2005·Brain Research. Brain Research Reviews·Galen D Kaufman
Aug 3, 1994·Biochemical Pharmacology·M K RitkeJ C Yalowich
Jan 1, 1991·Japanese Journal of Cancer Research : Gann·M YamaguchiA Matsukage
Jun 26, 1999·The Journal of Biological Chemistry·M W IzzoD J Hall
Dec 14, 1999·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·D KoyaG L King
Jan 29, 2003·The Journal of Biological Chemistry·Leonard M AndersonVictor J Dzau

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.