PMID: 8612Jul 1, 1976

A four parameter model for oral drug absorption

The Journal of Pharmacy and Pharmacology
L Saunders, T Natunen

Abstract

A method has been developed for assessing absorption parameters from plasma concentration-time results taken over a relatively short time period. In this method, the disposition function is simplified so as to reduce the number of parameters to be evaluated from the five of the two compartment disposition equation of four, and to avoid the requirement for the evaluation of a slow disposition rate constant. The measurments need not therefore be continued over a period long after absorption is complete. A suitable design for kinetic experiments using this method for interpreting the results, is described. A random noise statistical method is proposed for assessing the stability of the calculated parameters.

References

Sep 1, 1975·Journal of Pharmaceutical Sciences·E G LoveringW Tostowaryk
Apr 1, 1974·Journal of Pharmacokinetics and Biopharmaceutics·R Leclercq, G Copinschi
Oct 1, 1973·Journal of Pharmaceutical Sciences·W J Westlake

Citations

Jan 1, 1979·British Journal of Clinical Pharmacology·C M Castleden, C F George
Jun 13, 1981·British Medical Journal·A M HeagertyA Hedges
Jan 1, 1978·The Journal of Pharmacy and Pharmacology·L SaundersT Natunen

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Process of Absorption
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