A four-state Markov model of sleep-wakefulness dynamics along light/dark cycle in mice

PloS One
Leonel Perez-AtencioJuan A Barios

Abstract

Behavioral states alternate between wakefulness (wk), rapid eye movement (rem) and non-rem (nrem) sleep at time scale of hours i.e., light and dark cycle rhythms and from several tens of minutes to seconds (i.e., brief awakenings during sleep). Using statistical analysis of bout duration, Markov chains of sleep-wk dynamics and quantitative EEG analysis, we evaluated the influence of light/dark (ld) changes on brain function along the sleep-wk cycle. Bout duration (bd) histograms and Kaplan-Meier (km) survival curves of wk showed a bimodal statistical distribution, suggesting that two types of wk do exist: brief-wk (wkb) and long-wk (wkl). Light changes modulated specifically wkl bouts, increasing its duration during active/dark period. In contrast, wkb, nrem and rem bd histograms and km curves did not change significantly along ld cycle. Hippocampal eeg of both types of wk were different: in comparison wkb showed a lower spectral power in fast gamma and fast theta bands and less emg tone. After fitting a four-states Markov chain to mice hypnograms, moreover in states transition probabilities matrix was found that: in dark/active period, state-maintenance probability of wkl increased, and probability of wkl to nrem transition de...Continue Reading

References

Jan 1, 1986·Sleep·B Kemp, H A Kamphuisen
Jun 1, 1994·The American Journal of Physiology·J H Benington, H C Heller
May 23, 1997·Science·T Porkka-HeiskanenR W McCarley
Jun 27, 2001·Nature Neuroscience·G Aston-JonesM L Oshinsky
Mar 1, 2002·Journal of Sleep Research·Adrián Ocampo-Garcés, Ennio A Vivaldi
Nov 7, 2002·Physiology & Behavior·Michael GrözingerJoachim Röschke
Apr 18, 2003·Frontiers in Bioscience : a Journal and Virtual Library·Mircea Steriade
Jul 16, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Takatoshi MochizukiThomas E Scammell
Dec 8, 2004·Proceedings of the National Academy of Sciences of the United States of America·Chung-Chuan LoPlamen Ch Ivanov
Jul 15, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Maan Gee LeeBarbara E Jones
Nov 12, 2005·Journal of Neurophysiology·Yuichi TamakawaMitsuyuki Nakao
Apr 18, 2006·Nature Neuroscience·Sylvain Crochet, Carl C H Petersen
Apr 6, 2007·Journal of Neurophysiology·Cecilia G Diniz BehnNancy J Kopell
Apr 19, 2007·Journal of Biological Rhythms·A J K Phillips, P A Robinson
Apr 18, 2008·Journal of Neurophysiology·C G Diniz BehnT E Scammell
Oct 7, 2008·Behavioural Brain Research·Steven M Simasko, Sanjib Mukherjee
Jun 13, 2009·Physical Review Letters·J W KimD-U Jeong
Jun 27, 2009·Journal of Mathematical Biology·Michael J RempeDavid Terman
Mar 2, 2010·Neuron·Cristopher M Niell, Michael P Stryker
Sep 8, 2010·Journal of Neuroscience Methods·Blakeley B McShaneAbraham Wyner
Dec 22, 2010·Neuron·Clifford B SaperThomas E Scammell
Sep 7, 2011·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Michelle FleshnerCecilia G Diniz Behn
Oct 1, 2011·Journal of Sleep Research·Matt T BianchiRobert J Thomas
Oct 4, 2011·Sleep·Akifumi KishiYoshiharu Yamamoto
Jun 26, 2012·Neurobiology of Aging·Elizabeth B KlermanRichard E Kronauer
Jul 20, 2012·Physiological Reviews·Ritchie E BrownRobert W McCarley
May 21, 2013·Current Opinion in Neurobiology·Chloe AlexandreThomas E Scammell
Oct 19, 2013·Science·Lulu XieMaiken Nedergaard
Feb 18, 2014·Mathematical Biosciences·Victoria Booth, Cecilia G Diniz Behn
Sep 25, 2015·Neuron·Matthew J McGinleyDavid A McCormick
Oct 9, 2015·Sleep·Abigail F BranchCecilia Diniz Behn
Jan 15, 2016·Journal of Sleep Research·Alexander A BorbélyTom Deboer
May 22, 2016·Proceedings of the National Academy of Sciences of the United States of America·Gireesh GangadharanHee-Sup Shin
Jul 16, 2016·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Raffaele FerriGiuseppe Plazzi
Oct 7, 2016·Nature·Franz Weber, Yang Dan
Feb 24, 2017·Neuron·Thomas E ScammellJonathan O Lipton
Jun 21, 2017·Proceedings of the National Academy of Sciences of the United States of America·Anne Vassalli, Paul Franken

❮ Previous
Next ❯

Citations

Dec 11, 2019·Cerebral Cortex·Natalia Armas-CapoteTeresa Giraldez
Apr 19, 2020·Proceedings of the National Academy of Sciences of the United States of America·Timothy D WigginLeslie C Griffith

❮ Previous
Next ❯

Software Mentioned

spike
R
matlab
Sigmaplot

Related Concepts

Related Feeds

Basal Forebrain- Circuits

Basal forebrain is a region in the brain important for production of acetylcholine and is the major cholinergic output of the CNS. Discover the latest research on circuits in the basal forebrain here.

Basal Forebrain & Food Avoidance

Neurons in the basal forebrain play specific roles in regulating feeding. Here are the latest discoveries pertaining to the basal forebrain and food avoidance.

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.