A four-step model for the IL-6 amplifier, a regulator of chronic inflammations in tissue-specific MHC class II-associated autoimmune diseases.

Frontiers in Immunology
Masaaki Murakami, Toshio Hirano

Abstract

It is commonly thought that autoimmune diseases are caused by the breakdown of self-tolerance, which suggests the recognition of specific antigens by autoreactive CD4+ T cells contribute to the specificity of autoimmune diseases (Marrack et al., 2001; Mathis and Benoist, 2004). In several cases, however, even for diseases associated with class II major histocompatibility complex (MHC) alleles, the causative tissue-specific antigens recognized by memory/activated CD4+ T cells have not been established (Mocci et al., 2000; Skapenko et al., 2005). Rheumatoid arthritis (RA) and arthritis in F759 knock-in mice (F759 mice) are such examples (Atsumi et al., 2002; Brennan et al., 2002; Falgarone et al., 2009). These include associations with class II MHC and CD4 molecules; increased numbers of memory/activated CD4+ T cells; and improved outcomes in response to suppressions and/or deficiencies in class II MHC molecules, CD4+ T cells, and the T cell survival cytokine IL-7. Regarding the development of arthritis in F759 mice, it is not only the immune system, but also non-immune tissue that are involved, indicating that the importance of their interactions (Sawa et al., 2006, 2009; Ogura et al., 2008; Hirano, 2010; Murakami et al., 2011)....Continue Reading

Citations

Dec 17, 2014·Journal of Neuroscience Research·William M PryorLesley J White
Feb 26, 2013·Cell Reports·Masaaki MurakamiToshio Hirano
Oct 9, 2014·Frontiers in Immunology·Toshio Hirano
Jul 28, 2017·Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology·Ikuma Nakagawa, Masaaki Murakami
Jun 10, 2019·Bulletin of Experimental Biology and Medicine·L A MorozN F Soroka
Dec 20, 2017·Arquivos Brasileiros De Cirurgia Digestiva : ABCD = Brazilian Archives of Digestive Surgery·Renato Lamounier BarbieriPedro Luiz Squilacci Leme
Sep 14, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yuko OkuyamaMasaaki Murakami
Dec 15, 2015·Nature Reviews. Rheumatology·Iain B McInnesJohn D Isaacs
Jul 17, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jihye LeeMasaaki Murakami
Sep 10, 2017·Scientific Reports·Takatsugu OikeTakeshi Miyamoto
Jan 23, 2021·International Journal of Molecular Sciences·Giovanni ZarrilliMatteo Fassan
Dec 19, 2020·International Immunology·Toshio Hirano

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