A fourth case of 8p11 myeloproliferative disorder transforming to B-lineage acute lymphoblastic leukaemia. A case report

Acta Haematologica
M JabbarAl-ObaidiR Johnson

Abstract

A 56-year-old male presented with inguinal lymphadenopathy and leucocytosis (WBC 98 x 10(9)/l). Bone marrow morphology showed myeloid hyperplasia, with eosinophilia. Cytogenetic analysis showed no evidence of the Philadelphia chromosome, and fluorescence in situ hybridisation studies for the BCR/ABL fusion were negative. All cells examined showed the t(8;13)(p11;q12) translocation. Six weeks after presentation, the disease progressed to an acute lymphoblastic leukaemia (ALL). The lymphoblasts were CD19/CD10 dual positive. Cytogenetic analysis again showed the t(8;13) translocation, with no additional abnormalities. There have been at least 14 reported cases of the t(8;13) myeloproliferative disorder to date, of which only 3 transformed to B-lineage ALL: our case is the 4th.

Citations

Dec 29, 2007·The American Journal of Surgical Pathology·Francisco VegaLynne V Abruzzo
Apr 27, 2010·Cancer Genetics and Cytogenetics·Jeanna WelbornRobert Parks
Mar 17, 2010·Human Pathology·Courtney C JacksonRoberto N Miranda
May 15, 2007·Cancer Genetics and Cytogenetics·Ulrike BacherClaudia Haferlach
Jul 9, 2003·British Journal of Haematology·Barbara J Bain
Aug 2, 2006·European Journal of Haematology·Katsuya YamamotoToshimitsu Matsui

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