Oct 28, 2014

A framework for the analysis of symmetric and asymmetric divisions in developmental processes

BioRxiv : the Preprint Server for Biology
Pau RuéAlfonso Martinez Arias


Animal tissue development relies on precise generation and deployment of specific cell types into tissue sub-structures. Understanding how this process is regulated remains a major challenge of biology. In many tissues, development progresses through a sequence of dividing progenitor cells, each with decreasing potency, that balance their growth and differentiation. Dividing progenitor cells thus face a decision on whether their offspring shall differentiate or self-renew. This results in three possible modes of division (symmetric self-renewing, symmetric differentiating, and asymmetric) all of which have been observed in developing animal tissues. In some instances, the frequencies of occurrence of these division modes are incompatible with the possibility that sibling cells take the decision to differentiate independently of each other. Rather, an excess of symmetric divisions, both proliferating and differentiating, is usually observed in so far no general mechanism by which this fate entanglement takes place has been put forward. Here we propose a simple model of progenitor priming that provides a rationale on how the fate of sibling cells might be linked. Analysis of the model suggests that commitment to the cycle complet...Continue Reading

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Mentioned in this Paper

Oculodigitoesophagoduodenal Syndrome
Asymmetric Cell Division
Cell Division
Animal Tissue, NOS
Cell Differentiation Process
Cell Type
Stem Cell Self-Renewal
Stem Cells

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