PMID: 16634334Apr 26, 2006Paper

A framework for using epidemiological data for risk assessment

Human & Experimental Toxicology
G M H Swaen

Abstract

Data on health effects from human exposure to chemicals provide the most direct information for risk assessment. Despite their clear relevance for risk assessment and despite the frequently made statements by regulatory bodies to use epidemiological data whenever deemed appropriate, they are not always optimally used. In this article, a framework for using epidemiological data in risk assessment is presented. Before using an epidemiologic study as the basis for risk assessment, its quality must be evaluated. The quality criteria for such a study strongly depends on the type of association between the chemical and health effect in terms of its specificity and latency period. The framework is built on the type of health effect under consideration, whether it is a specific or non-specific effect and time window of the effect, whether it is an acute, sub-acute or long-term effect. Specificity and latency are aspects that have a great impact on the choice of research design and quality criteria that must be met in order to produce reliable results appropriate for risk assessment purposes. Although expert judgement will always play an important role, the framework can help to assess if a set of epidemiological data are sufficiently r...Continue Reading

References

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Citations

Feb 22, 2011·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·I-J WangK-Y Wu
Sep 25, 2012·The Annals of Occupational Hygiene·Virissa LentersDick Heederik
Jul 20, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·James W SimpkinsCharles B Breckenridge
Nov 28, 2013·BioMed Research International·Adrienne P StephensonHernan Flores-Rozas
Dec 17, 2008·Environmental Health Perspectives·Jelle VlaanderenUNKNOWN ECNIS Integrated Risk Assessment Group, European Union Network Of Excellence
Sep 17, 2008·Risk Analysis : an Official Publication of the Society for Risk Analysis·Jonathan I Levy
Sep 18, 2013·Critical Reviews in Toxicology·Lorenz R RhombergRichard A Becker
Nov 29, 2011·Regulatory Toxicology and Pharmacology : RTP·Karlene S LavelleHenk Vrijhof
Feb 23, 2010·Critical Reviews in Toxicology·Janneke G F HogervorstPiet A van den Brandt

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