A frequency-dependent switch from inhibition to excitation in a hippocampal unitary circuit

Nature
Masahiro MoriUrs Gerber

Abstract

The hippocampus, a brain structure essential for memory and cognition, is classically represented as a trisynaptic excitatory circuit. Recent findings challenge this view, particularly with regard to the mossy fibre input to CA3, the second synapse in the trisynaptic pathway. Thus, the powerful mossy fibre input to CA3 pyramidal cells might mediate both synaptic excitation and inhibition. Here we show, by recording from connected cell pairs in rat entorhinal-hippocampal slice cultures, that single action potentials in a dentate granule cell evoke a net inhibitory signal in a pyramidal cell. The hyperpolarization is due to disynaptic feedforward inhibition, which overwhelms monosynaptic excitation. Interestingly, this net inhibitory synaptic response changes to an excitatory signal when the frequency of presynaptic action potentials increases. The process responsible for this switch involves the facilitation of monosynaptic excitatory transmission coupled with rapid depression of inhibitory circuits. This ability to immediately switch the polarity of synaptic responses constitutes a novel synaptic mechanism, which might be crucial to the state-dependent processing of information in associative hippocampal networks.

References

Apr 1, 1986·The Journal of Physiology·R Miles, R K Wong
Aug 1, 1983·Journal of Neurophysiology·T H Brown, D Johnston
Sep 20, 1984·The Journal of Comparative Neurology·J Zimmer, B H Gähwiler
Jan 18, 1994·Proceedings of the National Academy of Sciences of the United States of America·S J SiegelJ H Morrison
Apr 1, 1993·Hippocampus·M W Jung, B L McNaughton
Feb 5, 2002·Journal of Neurophysiology·Yong LiangRichard Gray
Jun 1, 2002·Science·Kazu NakazawaSusumu Tonegawa
Jul 16, 2002·Nature Neuroscience·Darrell A HenzeGyörgy Buzsáki
Jun 20, 2003·Proceedings of the National Academy of Sciences of the United States of America·Stefan HallermannManfred Heckmann

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Citations

Jun 28, 2006·Pflügers Archiv : European journal of physiology·Josef BischofbergerPeter Jonas
Apr 3, 2012·Nature Neuroscience·Thomas AkamDimitri M Kullmann
Jul 16, 2013·Nature Neuroscience·David L HuntPablo E Castillo
Sep 4, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Francine M Benes
Jun 2, 2011·Proceedings of the National Academy of Sciences of the United States of America·Jeanne SterUrs Gerber
Nov 4, 2011·Proceedings of the National Academy of Sciences of the United States of America·Mirna KvajoJoseph A Gogos
Jan 20, 2010·Journal of Neural Engineering·A N IdeG J Brewer
Apr 25, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·John P WoockWarren M Grill
Nov 30, 2007·Neural Computation·Jeffrey J Lovelace, Krzysztof J Cios
Sep 5, 2008·PLoS Biology·Gábor MolnárGábor Tamás
Jan 11, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Scott A WilkeAnirvan Ghosh
Dec 5, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ricardo ScottDmitri A Rusakov
Nov 19, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Christine L TorborgChris J McBain
Jun 18, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·János SzabadicsIvan Soltesz
Apr 18, 2007·Proceedings of the National Academy of Sciences of the United States of America·Masahiro MoriUrs Gerber
Feb 20, 2014·Proceedings of the National Academy of Sciences of the United States of America·Federico Brandalise, Urs Gerber
Oct 3, 2012·The Journal of Physiology·Katalin Tóth
Dec 15, 2015·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Xiaoqi GengMasahiro Mori
Apr 15, 2006·The Journal of Physiology·Takuya SasakiYuji Ikegaya
Dec 22, 2015·Molecular and Cellular Neurosciences·Tomohiko MaruoMasahiro Mori
Aug 12, 2009·Journal of Neuroscience Methods·Gregory J BrewerBruce C Wheeler
Aug 8, 2009·Experimental Neurology·Alicia L Jensen, Dominique M Durand
Dec 17, 2015·Nature Communications·Patrick Sweeney, Yunlei Yang
Oct 22, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Hui YePeter L Carlen
Oct 16, 2007·Neuroscience Research·Shigetomo SuyamaHiromu Yawo
May 12, 2007·Current Opinion in Neurobiology·Kenneth A Pelkey, Chris J McBain
Jan 26, 2006·Hippocampus·Rosa CossartChristophe Bernard
Apr 20, 2011·The European Journal of Neuroscience·Mario TreviñoRafael Gutiérrez
Sep 30, 2010·IEEE Transactions on Neural Networks·John J WadeHeather M Sayers
Aug 27, 2005·Trends in Neurosciences·Gilad SilberbergHenry Markram
Sep 25, 2015·Neuron·Aaron D MilsteinJeffrey C Magee
Jul 17, 2015·Neuron·Johan WinnubstChristian Lohmann

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