A Fresh View on Lymph Node Organogenesis

Trends in Immunology
Lucas Onder, Burkhard Ludewig

Abstract

Lymph nodes (LNs) are strategically positioned outposts of the immune system that underpin regional immune surveillance. The current model describing LN formation in mice is based on a two cell-type interaction scheme with lymphoid tissue inducer cells regulating the activation of mesenchymal lymphoid tissue organizer cells. We highlight here the key role of lymphatic endothelial cells during the initiation of LN formation. The involvement of lymphatic endothelial cells as an additional organizer cell type in LN organogenesis unveils multiple control levels that govern the generation of lymphoid organs. Moreover, the linkage between lymphangiogenic and lymphvasculogenic processes and guidance of the accumulation and activation of lymphoid tissue inducer cells in the embryo suggests that LN formation may be driven on demand by developing organ systems.

Citations

Apr 13, 2019·Immunological Reviews·Christian Perez-ShibayamaBurkhard Ludewig
Apr 13, 2019·Immunological Reviews·Nadine EckertReinhold Förster
Apr 3, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ryan D HeimrothIrene Salinas
May 28, 2020·Arteriosclerosis, Thrombosis, and Vascular Biology·Ying ShaoXiaofeng Yang
May 21, 2019·Frontiers in Immunology·Rae H FarnsworthSteven A Stacker
Nov 21, 2020·Nature Reviews. Immunology·Ronen AlonDavid J Topham
Jan 6, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Catarina Gago da GraçaReina E Mebius
Jan 6, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Natalia Barbara PikorBurkhard Ludewig
Jan 23, 2020·Cell Reports·Mario NovkovicBurkhard Ludewig
Apr 14, 2019·Human Immunology·Jeffrey L Platt, Marilia Cascalho
Mar 7, 2021·International Journal of Medical Microbiology : IJMM·Mangge ZouJochen Huehn
May 29, 2021·Immunological Reviews·Mechthild LütgeBurkhard Ludewig
Jun 15, 2021·Frontiers in Immunology·Anna Johansson-Percival, Ruth Ganss
Jul 10, 2021·Cellular and Molecular Life Sciences : CMLS·Lionel GillotAgnès Noël
Jan 16, 2022·Proceedings of the National Academy of Sciences of the United States of America·Abdouramane CamaraChristopher G Mueller

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