A fully automated artificial intelligence method for non-invasive, imaging-based identification of genetic alterations in glioblastomas.

Scientific Reports
Evan CalabreseSoonmee Cha

Abstract

Glioblastoma is the most common malignant brain parenchymal tumor yet remains challenging to treat. The current standard of care-resection and chemoradiation-is limited in part due to the genetic heterogeneity of glioblastoma. Previous studies have identified several tumor genetic biomarkers that are frequently present in glioblastoma and can alter clinical management. Currently, genetic biomarker status is confirmed with tissue sampling, which is costly and only available after tumor resection or biopsy. The purpose of this study was to evaluate a fully automated artificial intelligence approach for predicting the status of several common glioblastoma genetic biomarkers on preoperative MRI. We retrospectively analyzed multisequence preoperative brain MRI from 199 adult patients with glioblastoma who subsequently underwent tumor resection and genetic testing. Radiomics features extracted from fully automated deep learning-based tumor segmentations were used to predict nine common glioblastoma genetic biomarkers with random forest regression. The proposed fully automated method was useful for predicting IDH mutations (sensitivity = 0.93, specificity = 0.88), ATRX mutations (sensitivity = 0.94, specificity = 0.92), chromosome 7/1...Continue Reading

References

Mar 11, 2005·The New England Journal of Medicine·Monika E HegiRoger Stupp
Dec 20, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Manish AghiFred G Barker
Apr 26, 2007·The American Journal of Pathology·Hiroko Ohgaki, Paul Kleihues
Sep 6, 2007·Brain : a Journal of Neurology·Dietmar KrexUNKNOWN German Glioma Network
Dec 30, 2008·The Lancet Oncology·Sergei V Jargin
Feb 21, 2009·The New England Journal of Medicine·Hai YanDarell D Bigner
Jan 1, 2009·Medical Image Computing and Computer-assisted Intervention : MICCAI·Ilya LevnerRoss Mitchell
Sep 3, 2011·The Journal of Molecular Diagnostics : JMD·Inês CrespoMaría Dolores Tabernero
Oct 8, 2011·NeuroImage·Mark JenkinsonStephen M Smith
Feb 1, 2012·The Cancer Journal·Michael WellerWolfgang Wick
Dec 15, 2012·Cancer Genetics·McKinsey L Goodenberger, Robert B Jenkins
Mar 28, 2013·Current Neurology and Neuroscience Reports·Adam L CohenHoward Colman
Dec 11, 2014·IEEE Transactions on Medical Imaging·Bjoern H MenzeKoen Van Leemput
May 16, 2015·The American Journal of Pathology·Ines CrespoMaria Dolores Tabernero
Sep 5, 2015·Neuroradiology·David A GutmanHugo J W L Aerts
Sep 26, 2015·AJNR. American Journal of Neuroradiology·K YamashitaH Honda
Jun 10, 2016·Medical Physics·Panagiotis KorfiatisBradley J Erickson
Jan 28, 2017·Scientific Reports·Michiru NishitaYasuhiro Minami
Jun 11, 2017·Journal of Digital Imaging·Zeynettin AkkusBradley J Erickson
Sep 3, 2017·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M TouatK L Ligon
Nov 3, 2017·Cancer Research·Joost J M van GriethuysenHugo J W L Aerts
Nov 24, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ken ChangJayashree Kalpathy-Cramer
May 24, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Chia-Feng LuCheng-Yu Chen

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Citations

Aug 11, 2021·Neurologia Medico-chirurgica·Manabu KinoshitaHaruhiko Kishima
Nov 3, 2021·Nano Convergence·Jessica A Kemp, Young Jik Kwon

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Methods Mentioned

BETA
feature extraction
biopsy
PCR

Software Mentioned

Tensorflow
FSL
Invivo
Eddy
RandomizedSearchCV
PyRadiomics
RandomForestRegressor
Python
Brain Extraction Tool ( BET )

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