A Fully-Automatic Multiparametric Radiomics Model: Towards Reproducible and Prognostic Imaging Signature for Prediction of Overall Survival in Glioblastoma Multiforme

Scientific Reports
Qihua LiZhi-Cheng Li

Abstract

In fully-automatic radiomics model for predicting overall survival (OS) of glioblastoma multiforme (GBM) patients, the effect of image standardization parameters such as voxel size, quantization method and gray level on model reproducibility and prognostic performance are still unclear. In this study, 45792 multiregional radiomics features were automatically extracted from multi-modality MR images with different voxel sizes, quantization methods, and gray levels. The feature reproducibility and prognostic performance were assessed. Multiparametric and fixed-parameter radiomics signatures were constructed based on a training cohort (60 patients). In an independent validation cohort (32 patients), the multiparametric signature achieved better performance for OS prediction (C-Index = 0.705, 95% CI: 0.672, 0.738) and significant stratification of patients into high- and low-risk groups (P = 0.0040, HR = 3.29, 95% CI: 1.40, 7.70), which outperformed the fixed-parameter signatures and conventional factors such as age, Karnofsky Performance Score and tumor volume. This study demonstrated that voxel size, quantization method and gray level had influence on reproducibility and prognosis of radiomics features for GBM OS prediction. An au...Continue Reading

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Citations

Jun 28, 2018·The British Journal of Radiology·Simon A KeekHenry C Woodruff
Jan 23, 2019·Radiology·Jeffrey D RudieSuyash Mohan
Feb 23, 2019·PloS One·Tommy LöfstedtAnders Garpebring
Jul 5, 2019·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Ji Eun ParkHo Sung Kim
May 18, 2020·Medical Physics·Michele AvanzoIssam El Naqa
Sep 3, 2020·Cancers·Enrico Capobianco, Jun Deng
Nov 30, 2019·Frontiers in Computational Neuroscience·Leon WeningerDorit Merhof
Jun 20, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Martina SolliniMargarita Kirienko
Jul 31, 2020·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Ji Eun ParkHo Sung Kim
Feb 2, 2021·Neuro-oncology Advances·Niha BeigPallavi Tiwari
May 8, 2021·British Journal of Cancer·Gagandeep SinghVadim Spektor
Jun 22, 2021·Nature Reviews. Neurology·Marion Smits
Jul 15, 2020·Academic Radiology·Sonal GoreMadhura Ingalhalikar

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Methods Mentioned

BETA
features extraction

Software Mentioned

R package glmnet
GLCM
BRATS
R
LASSO
OCCC
tile
Matlab

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