PMID: 9541131Apr 16, 1998Paper

A functional defect in hereditary haemochromatosis monocytes and monocyte-derived macrophages

European Journal of Clinical Investigation
E MouraJ J Marx

Abstract

Hereditary haemochromatosis (HH) is a disease of the metabolism of iron characterized by increased iron absorption and heavy parenchymal iron deposition, but with the presence of little iron in the mononuclear phagocytic system (MPS). To investigate the role of the MPS, the phagocytic ability of HH monocytes (MNs) and in vitro monocyte-derived macrophages (MDMs) was studied. HH patients with different degrees of iron accumulation were chosen. We observed that HH patients' MNs and MDMs have a significantly decreased ability to phagocytose rabbit red blood cells (RRBCs) and that HH MNs possess a significantly decreased capacity to phagocytose Staphylococcus aureus (S. aureus). The decrease in the ability to phagocytose S. aureus, however, was kinetic in nature, explaining the absence of increased prevalence of bacterial infections among HH patients. Both RRBCs and S. aureus were preopsonized with heat-inactivated serum. No alteration in the complement-dependent phagocytosis of Cryptococcus neoformans was demonstrated when normal human serum was used. The phagocytosis defect was observed in 100% of HH patients and was independent of the magnitude of iron overload, age or liver damage, and affected the antibody-mediated uptake of b...Continue Reading

References

Jan 4, 1979·The New England Journal of Medicine·P A BlakeP C Heublein
Jun 1, 1990·Journal of Leukocyte Biology·R AndreesenG W Löhr
Aug 19, 1991·Ugeskrift for laeger·H K Andersen
May 1, 1989·Journal of Internal Medicine·L L OlesenP R Knudsen
Jan 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H KondoP Aisen
Sep 1, 1986·The Journal of Infection·M AbbottJ L Cunningham
Nov 14, 1985·The New England Journal of Medicine·C NiederauG Strohmeyer
Dec 10, 1983·Lancet·R M Robins-Browne, J K Prpic
May 1, 1984·The Journal of Infection·B S van AsbeckJ Verhoef
Feb 20, 1982·British Medical Journal·B S van AsbeckJ Verhoef
Aug 14, 1982·British Medical Journal·K MelbyS A Nordbø
Feb 11, 1983·Journal of Immunological Methods·R AndreesenG W Löhr
Oct 1, 1980·American Journal of Clinical Pathology·E BouzaJ Martinez-Beltran
Mar 1, 1995·Blood Reviews·G J Kontoghiorghes, E D Weinberg
Oct 27, 1994·The New England Journal of Medicine·F GomezA D Schreiber
Feb 28, 1996·Clinica Chimica Acta; International Journal of Clinical Chemistry·D L WitteF A Mitros
Mar 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·S ParkkilaW S Sly
May 1, 1997·The New England Journal of Medicine·M SantosJ J Marx
Jun 1, 1997·The Journal of Infectious Diseases·A MencacciL Romani

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Citations

Mar 29, 2003·Journal of Hepatology·Kim R BridleGrant A Ramm
Aug 17, 2000·The Journal of Infectious Diseases·S Cunningham-RundlesM De Sousa
Nov 26, 2003·Infection and Immunity·Houman Ashrafian
Jul 13, 2004·Gut·C GascheG Weiss
Aug 25, 2015·International Journal for Parasitology·Dominique F LeitnerJames R Connor
Sep 30, 2009·Seminars in Hematology·Carole Beaumont, Constance Delaby
Nov 12, 2005·European Journal of Clinical Investigation·G Weiss, V R Gordeuk
Jun 30, 2007·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Fida A KhanRashida A Khakoo
Jun 30, 2000·American Heart Journal·L R ZacharskiL M Schwartz
Jul 23, 2016·Frontiers in Cellular and Infection Microbiology·Halie K MillerVictoria Auerbuch
Oct 8, 2009·European Journal of Gastroenterology & Hepatology·Pierre-Alexandre KrayenbuehlGeorg Schulthess
Mar 1, 1999·Acta Neuropsychiatrica·W van den Brink
Mar 19, 2003·Critical Reviews in Biochemistry and Molecular Biology·Mitchell Knutson, Marianne Wessling-Resnick
May 12, 2005·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·J V LunnD Bouchier-Hayes
Mar 12, 2002·European Journal of Clinical Investigation·Günter Weiss

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