A functional drug delivery platform for targeting and imaging cancer cells based on Pluronic F127

Journal of Biomaterials Science. Polymer Edition
Denghao ZhangMinbo Lan

Abstract

Functional polymeric micelles play an important role in the efficient delivery of therapeutic drugs into tumours. In this study, a functional drug delivery platform with ligands for targeting and fluorescent imaging was designed based on Pluronic F127 (PF127). Using folic acid (FA) and fluorescein isothiocyanate (FITC) to chemically conjugate with PF127, two functional polymers, Pluronic F127-FA (PF127-FA) and Pluronic F127-FITC (PF127-FITC), were synthesized. Solasodine-loaded micelles were then prepared via the thin-film hydration method. By employing A549 and HeLa cells, the results of in vitro cell assays performed using confocal laser scanning microscopy and flow cytometry suggested that the proposed micelles could provide the desired specific targeting and fluorescent imaging functions. In addition, the results of in vitro cytotoxicity experiments showed that the growth inhibition rates of A549 and HeLa cells treated with solasodine-loaded micelles were remarkably higher than those of cells treated with free solasodine. Solasodine-loaded micelles exhibited a more distinct inhibitory effect against HeLa cells than against A549 cells. Thus, an effective drug delivery system for targeting and imaging cancer cells was developed.

References

Jan 2, 2007·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Kevin Letchford, Helen Burt
May 8, 2007·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Diego A Chiappetta, Alejandro Sosnik
Mar 11, 2008·Molecular Biotechnology·T TharmalingamM Butler
Jun 7, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Elena V Batrakova, Alexander V Kabanov
Jul 26, 2008·Nature Nanotechnology·Dan PeerRobert Langer
Dec 18, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Atsushi YamadaYoshie Maitani
Aug 14, 2010·The Journal of Physical Chemistry. B·Yukio TominagaTakahiro Sato
Mar 2, 2011·Molecules and Cells·Ki Hyun BaeTae Gwan Park
Mar 16, 2011·Journal of Agricultural and Food Chemistry·Sinead Eileen MilnerAnita Rose Maguire
Mar 25, 2011·Advanced Materials·José A BarretoLeone Spiccia
May 7, 2011·Bioconjugate Chemistry·Alice GalbiatiAlessandro Desideri
Mar 6, 2012·Chemical Society Reviews·Nazila KamalyOmid C Farokhzad
Apr 30, 2013·Materials Science & Engineering. C, Materials for Biological Applications·Yong-Yong LiTian-Bin Ren
Nov 28, 2013·ACS Chemical Neuroscience·Leyuan XuYue Wu
Jan 15, 2014·European Journal of Medicinal Chemistry·Verónica Carrasco-SánchezLeonardo S Santos
Jul 2, 2014·Drug Discovery Today·L Saenz del BurgoG Orive

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Citations

Jun 7, 2018·Anais Da Academia Brasileira De Ciências·Mariana Q MesquitaMaria Amparo F Faustino
Jan 16, 2018·Artificial Cells, Nanomedicine, and Biotechnology·Atmaram PawarC Bothiraja

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Methods Mentioned

BETA
flow cytometry
nuclear magnetic resonance
infrared
infrared spectroscopy
dynamic light scattering
fluorescence imaging

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