A functional homologue of mammalian secretory component exists in chickens

European Journal of Immunology
J V PeppardP Hesketh

Abstract

The existence of a molecule in chickens homologous to the secretory component of mammals has long been in dispute. An intravenous injection of [14C]fucose was given to chickens as a marker for newly synthesized glycoproteins and then unlabeled human IgA was injected intravenously half an hour later. It was shown that the human IgA subsequently appeared in the bile of the chickens combined with a [14C]fucose-labeled molecule; the chicken IgA in these bile samples was similarly labeled. Radiolabeled human secretory IgA was not transported in large amounts across the chicken liver in vivo and neither was purified chicken bile IgA. These results indicate that a molecule exists in chickens which behaves in a manner analogous to mammalian secretory component.

References

Feb 1, 1978·The Journal of Experimental Medicine·E OrlansJ Hall
Feb 28, 1978·Biochemical and Biophysical Research Communications·P J Fraker, J C Speck
Aug 15, 1975·European Journal of Biochemistry·R A Laskey, A D Mills
Sep 6, 1969·Lancet·R A ThompsonW T Cooke
Jul 1, 1974·European Journal of Immunology·M E RoseN Buttress
Jul 1, 1974·European Journal of Immunology·D KatzR Arnon
Jun 1, 1974·European Journal of Biochemistry·I Björk, E Lindh
Aug 1, 1972·Immunochemistry·E Orlans, M E Rose
Jul 1, 1981·European Journal of Immunology·M E RoseP Hesketh
Sep 15, 1980·The Biochemical Journal·B M MullockE Orlans

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Citations

May 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·W R Brown, T M Kloppel
Apr 14, 2006·Veterinary Research·Sven ReeseBernd Kaspers
Dec 18, 2019·Annual Review of Animal Biosciences·Yi SunYaofeng Zhao
Jul 15, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Beth M StadtmuellerPamela J Bjorkman
Mar 1, 1986·European Journal of Immunology·J V PeppardA P Mockett
Jul 1, 1996·Clinical Microbiology Reviews·H S Lillehoj, J M Trout

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