A functional magnetic resonance imaging study of working memory abnormalities in schizophrenia

Biological Psychiatry
Matthew R JohnsonGodfrey D Pearlson

Abstract

Previous neuroimaging studies of working memory (WM) in schizophrenia, typically focusing on dorsolateral prefrontal cortex, yield conflicting results, possibly because of varied choice of tasks and analysis techniques. We examined neural function changes at several WM loads to derive a more complete picture of WM dysfunction in schizophrenia. We used a version of the Sternberg Item Recognition Paradigm to test WM function at five distinct loads. Eighteen schizophrenia patients and 18 matched healthy controls were scanned with functional magnetic resonance imaging at 3 Tesla. Patterns of both overactivation and underactivation in patients were observed depending on WM load. Patients' activation was generally less responsive to load changes than control subjects', and different patterns of between-group differences were observed for memory encoding and retrieval. In the specific case of successful retrieval, patients recruited additional neural circuits unused by control subjects. Behavioral effects were generally consistent with these imaging results. Differential findings of overactivation and underactivation may be attributable to patients' decreased ability to focus and allocate neural resources at task-appropriate levels. A...Continue Reading

References

Dec 1, 1992·Archives of General Psychiatry·S Park, P S Holzman
Aug 5, 1966·Science·S Sternberg
Feb 1, 1996·The American Journal of Psychiatry·D A Yurgelun-ToddP F Renshaw
Oct 29, 1996·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·J D CohenR C O'Reilly
Dec 1, 1996·Archives of General Psychiatry·D Servan-SchreiberS Steingard
Feb 21, 1998·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·J H CallicottD R Weinberger
Dec 23, 1998·Archives of General Psychiatry·B E WexlerP S Goldman-Rakic
May 26, 1999·Proceedings of the National Academy of Sciences of the United States of America·B Rypma, M D'Esposito
Jul 27, 2000·Human Brain Mapping·J L LancasterP T Fox
Mar 20, 2001·Archives of General Psychiatry·D M BarchJ D Cohen
Jun 30, 2001·The American Journal of Psychiatry·W M PerlsteinJ D Cohen
Jun 12, 2002·Psychiatry Research·Avishai HenikLynn C Robertson
Jun 20, 2002·IEEE Transactions on Medical Imaging·L FreireJ F Mangin
Feb 22, 2003·NeuroImage·Dick J VeltmanRaymond J Dolan
Nov 26, 2003·The American Journal of Psychiatry·Joseph H CallicottDaniel R Weinberger
Apr 22, 2004·Schizophrenia Research·J M JansmaR S Kahn

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Citations

Aug 5, 2009·Archives of General Psychiatry·Michael J MinzenbergDavid C Glahn
Mar 12, 2008·Annals of Biomedical Engineering·Andreas WindemuthGualberto Ruaño
Jul 8, 2011·Psychological Medicine·A Guerrero-PedrazaE Pomarol-Clotet
Jul 8, 2011·Psychological Medicine·S EhrlichD J Holt
Aug 21, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Daniel Paul Eisenberg, Karen Faith Berman
Apr 30, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Kristen M HautAngus MacDonald
Nov 8, 2008·Proceedings of the National Academy of Sciences of the United States of America·Joshua L RoffmanDara S Manoach
Apr 5, 2011·Journal of Clinical and Experimental Neuropsychology·Sari MukkalaJuha Veijola
Dec 2, 2008·Schizophrenia Bulletin·S G PotkinUNKNOWN FBIRN
Feb 24, 2010·Schizophrenia Bulletin·Karla Becerril, Deanna Barch
Apr 3, 2008·Neuroreport·Emanuela TuraSteven G Potkin
Nov 19, 2013·Biological Psychiatry·Teal S EichEdward E Smith
Jan 28, 2012·Cognitive, Affective & Behavioral Neuroscience·Tara A NiendamCameron S Carter
Feb 22, 2012·Biological Psychiatry·Matthijs G BossongNick F Ramsey
Dec 16, 2011·Trends in Cognitive Sciences·Deanna M Barch, Alan Ceaser
Jul 26, 2011·Psychiatry Research·Kathy Burton AvsarAdrienne Carol Lahti
Dec 15, 2010·Schizophrenia Research·Fabien C SchneiderFrançois Lang
Jan 26, 2010·Schizophrenia Research·Miyoung A KimJessica A Turner
Oct 20, 2009·Psychiatry Research·Jared Xavier Van Snellenberg
Apr 29, 2009·Psychiatry Research·Sebastian WaltherThomas Jörg Müller
Oct 3, 2014·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Deanna M Barch, Julia M Sheffield
Apr 9, 2016·Biological Psychiatry·Jared X Van SnellenbergAnissa Abi-Dargham

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