A functional magnetic resonance imaging study of verbal working memory in young people at increased familial risk of depression.

Biological Psychiatry
Zola N MannieRay Norbury

Abstract

Patients with depression show abnormalities in the neural circuitry supporting working memory. These abnormalities apparently persist into clinical remission, raising the possibility that they might be trait markers indicating vulnerability to depression. We studied 17 young people who had a depressed parent but no personal history of depressive illness (FH) and 15 healthy control subjects with no family history of depression. Participants performed a verbal working memory task of varying cognitive load (n-back) while undergoing functional magnetic resonance imaging scanning. We used multiple regression analyses to assess overall capacity (1-, 2-, 3-back vs. 0-back) as well as linear and quadratic modulation of cognitive demand. Performance accuracy and response latency did not differ between groups, and overall capacity was similar. However, for both linear and quadratic load response activity, FH participants showed greater activation in lateral occipital cortex, superior temporal cortex, and superior parietal cortex. Our data suggest that, as in depressed patients, maintenance of task performance in FH participants is associated with a significant increase in the load-response activity of the cortical regions involved in wor...Continue Reading

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Citations

Sep 2, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sandra CornelisseTom Smeets
Oct 7, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jonathan P RoiserBarbara J Sahakian
Oct 18, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Roel J T MockingCatherine J Harmer
Dec 25, 2013·Biological Psychiatry·Froukje E de VriesOdile A van den Heuvel
Jan 21, 2016·Human Brain Mapping·Camille PiguetPatrik Vuilleumier
Sep 15, 2015·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Emanuel SchwarzAndreas Meyer-Lindenberg
Mar 10, 2016·Human Brain Mapping·Milutin KosticMassimo Filippi
Feb 15, 2015·Neuroscience Bulletin·Min-Fang Kuo, Michael A Nitsche
Oct 6, 2014·Journal of Affective Disorders·Kensuke KodamaTakanori Kochiyama
Nov 13, 2013·Journal of Affective Disorders·Madhukar H Trivedi, Tracy L Greer
Sep 18, 2010·The International Journal of Neuropsychopharmacology·Matthew J TaylorPhilip J Cowen
Oct 17, 2019·Psychological Medicine·Susannah E MurphyCatherine J Harmer

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