Abstract
A new functional magnetic resonance imaging (fMRI) technique is proposed based on nulling the extravascular gray matter (GM) signal, using a spatially nonselective inversion pulse. The remaining MR signal provides cerebral blood volume (CBV) information from brain activation. A theoretical framework is provided to characterize the sources of GM-nulled (GMN) fMRI signal, effects of partial voluming of cerebrospinal fluid (CSF) and white matter, and behaviors of GMN fMRI signal during brain activation. Visual stimulation paradigm was used to explore the GMN fMRI signal behavior in the human brain at 3T. It is shown that the GMN fMRI signal increases by 7.2%+/-1.5%, which is two to three times more than that obtained with vascular space occupancy (VASO)-dependent fMRI (-3.2%+/-0.2%) or blood oxygenation level-dependent (BOLD) fMRI (2.9%+/-0.7%), using a TR of 3,000 ms and a resolution of 2 x 2 x 5 mm(3). Under these conditions the fMRI signal-to-noise ratio (SNR(fMRI)) for BOLD, GMN, and VASO images was 4.97+/-0.76, 4.56+/-0.86, and 2.43+/-1.06, respectively. Our study shows that both signal intensity and activation volume in GMN fMRI depend on spatial resolution because of partial voluming from CSF. It is shown that GMN fMRI is a...Continue Reading
References
Jun 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·K K KwongR Turner
Jul 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·S OgawaK Ugurbil
Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S OgawaD W Tank
Jan 1, 1989·Annals of Biomedical Engineering·M SharanA S Popel
Mar 1, 1985·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·P Herscovitch, M E Raichle
Jul 1, 1995·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J L BoxermanR M Weisskoff
Mar 1, 1993·Biophysical Journal·S OgawaK Ugurbil
Sep 1, 1993·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S LaiR Friedland
Sep 1, 1996·Cerebral Cortex·T A WoolseyL Wei
Jun 1, 1997·NMR in Biomedicine·E C WongL R Frank
Feb 14, 1998·Nature Medicine·P C van ZijlR A Kauppinen
Jun 11, 1998·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R B BuxtonL R Frank
May 3, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·H ItoI Kanno
Aug 30, 2001·Proceedings of the National Academy of Sciences of the United States of America·T Q DuongS G Kim
Jan 2, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·M J SilvennoinenP C M van Zijl
Jul 24, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Hanzhang LuPeter C M Van Zijl
Jan 6, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Hanzhang LuXavier Golay
Aug 25, 2004·NeuroImage·Kâmil UludağRichard B Buxton
Aug 31, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Hanzhang LuPeter C M van Zijl
Nov 25, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Yihong YangElliot A Stein
Mar 31, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Hanzhang Lu, Peter C M van Zijl
Apr 6, 2005·NeuroImage·R D HogeD A Boas
Jun 23, 2005·Journal of Magnetic Resonance Imaging : JMRI·Hanzhang LuPeter C M van Zijl
Nov 10, 2005·NeuroImage·Hong GuYihong Yang
Jul 25, 2006·The British Journal of Radiology·E T PetersenX Golay
Nov 1, 2006·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Manus J DonahuePeter C M van Zijl
Jul 27, 2007·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·A Scouten, R T Constable
Citations
Jun 26, 2010·Human Brain Mapping·Benedikt A Poser, David G Norris
Jan 29, 2013·NMR in Biomedicine·Hanzhang LuPeter C M van Zijl
May 16, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jun HuaPeter C M van Zijl
Aug 22, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Laurentius HuberRobert Turner
Jan 17, 2012·NeuroImage·Hanzhang Lu, Peter C M van Zijl
Mar 27, 2010·NeuroImage·Tao Jin, Seong-Gi Kim
Nov 15, 2011·NeuroImage·Yuji ShenRisto A Kauppinen
Jun 9, 2020·Progress in Neurobiology·Laurentius HuberBenedikt A Poser
May 27, 2021·NeuroImage·Laurentius Renzo HuberAneurin J Kennerley
Oct 9, 2021·Frontiers in Neuroscience·Mahsa ZoraghiNikolaus Weiskopf