A functional magnetic resonance imaging technique based on nulling extravascular gray matter signal

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Yuji ShenX Golay

Abstract

A new functional magnetic resonance imaging (fMRI) technique is proposed based on nulling the extravascular gray matter (GM) signal, using a spatially nonselective inversion pulse. The remaining MR signal provides cerebral blood volume (CBV) information from brain activation. A theoretical framework is provided to characterize the sources of GM-nulled (GMN) fMRI signal, effects of partial voluming of cerebrospinal fluid (CSF) and white matter, and behaviors of GMN fMRI signal during brain activation. Visual stimulation paradigm was used to explore the GMN fMRI signal behavior in the human brain at 3T. It is shown that the GMN fMRI signal increases by 7.2%+/-1.5%, which is two to three times more than that obtained with vascular space occupancy (VASO)-dependent fMRI (-3.2%+/-0.2%) or blood oxygenation level-dependent (BOLD) fMRI (2.9%+/-0.7%), using a TR of 3,000 ms and a resolution of 2 x 2 x 5 mm(3). Under these conditions the fMRI signal-to-noise ratio (SNR(fMRI)) for BOLD, GMN, and VASO images was 4.97+/-0.76, 4.56+/-0.86, and 2.43+/-1.06, respectively. Our study shows that both signal intensity and activation volume in GMN fMRI depend on spatial resolution because of partial voluming from CSF. It is shown that GMN fMRI is a...Continue Reading

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Citations

May 16, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jun HuaPeter C M van Zijl
Aug 22, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Laurentius HuberRobert Turner
Jan 17, 2012·NeuroImage·Hanzhang Lu, Peter C M van Zijl
Jun 9, 2020·Progress in Neurobiology·Laurentius HuberBenedikt A Poser
May 27, 2021·NeuroImage·Laurentius Renzo HuberAneurin J Kennerley

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Software Mentioned

IDL
MCFLIRT
FEAT
Linux
VASO
FSL
FEAT ( FMRI Expert Analysis Tool )
FAST ( FMRIB s Atomated Segmentation Tool )
MRIcro
FILM FMRIB

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