A functional polymorphism in the promoter region of MAOA gene is associated with daytime sleepiness in healthy subjects

Journal of the Neurological Sciences
Diego A OjedaDiego A Forero

Abstract

Excessive daytime sleepiness (EDS) is one of the main causes of car and industrial accidents and it is associated with increased morbidity and alterations in quality of life. Prevalence of EDS in the general population around the world ranges from 6.2 to 32.4%, with a heritability of 38-40%. However, few studies have explored the role of candidate genes in EDS. Monoamine oxidase A (MAOA) gene has an important role in the regulation of neurotransmitter levels and a large number of human behaviors. We hypothesized that a functional VNTR in the promoter region of the MAOA gene might be associated with daytime sleepiness in healthy individuals. The Epworth sleepiness scale (ESS) was applied to 210 Colombian healthy subjects (university students), which were genotyped for MAOA-uVNTR. MAOA-uVNTR showed a significant association with ESS scores (p = 0.01): 3/3 genotype carriers had the lowest scores. These results were supported by differences in MAOA-uVNTR frequencies between diurnal somnolence categories (p = 0.03). Our finding provides evidence for the first time that MAOA-uVNTR has a significant association with EDS in healthy subjects. Finally, these data suggest that functional variations in MAOA gene could have a role in other ...Continue Reading

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Citations

Nov 12, 2015·Depression Research and Treatment·Yeimy González-GiraldoDiego A Forero
Jun 9, 2016·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Yeimy González-GiraldoDiego A Forero
Nov 18, 2017·Archives of Physiology and Biochemistry·Yeimy González-GiraldoDiego A Forero
Dec 30, 2014·World Journal of Psychiatry·Diego A ForeroGeorge Perry
Dec 19, 2016·The Open Neurology Journal·Diego A ForeroGeorge Perry
Aug 11, 2015·Current Sleep Medicine Reports·David T Plante
Feb 10, 2017·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Filiz OzenIsmet Berber
Feb 6, 2017·Molecular Neurobiology·Daniela Morales-LaraEric Murillo-Rodríguez

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