A functional proteomics approach to the comprehension of sarcoidosis

Journal of Proteomics
C LandiP Rottoli

Abstract

Pulmonary sarcoidosis (Sar) is an idiopathic disease histologically typified by non-caseating epitheliod cell sarcoid granulomas. A cohort of 37 Sar patients with chronic persistent pulmonary disease was described in this study. BAL protein profiles from 9 of these Sar patients were compared with those from 8 smoker (SC) and 10 no-smoker controls (NSC) by proteomic approach. Principal Component Analysis was performed to clusterize the samples in the corresponding conditions highlighting a differential pattern profiles primarily in Sar than SC. Spot identification reveals thirty-four unique proteins involved in lipid, mineral, and vitamin Dmetabolism, and immuneregulation of macrophage function. Enrichment analysis has been elaborated by MetaCore, revealing 14-3-3ε, α1-antitrypsin, GSTP1, and ApoA1 as "central hubs". Process Network as well as Pathway Maps underline proteins involved in immune response and inflammation induced by complement system, innate inflammatory response and IL-6signalling. Disease Biomarker Network highlights Tuberculosis and COPD as pathologies that share biomarkers with sarcoidosis. In conclusion, Sar protein expression profile seems more similar to that of NSC than SC, conversely to other ILDs. Moreove...Continue Reading

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Citations

Aug 28, 2016·The Journal of Allergy and Clinical Immunology·Maria-Jose Martinez-BravoSusanne Gabrielsson
Sep 27, 2018·Expert Review of Proteomics·Claudia LandiPaola Rottoli
Sep 6, 2019·Clinical and Experimental Medicine·L BergantiniE Bargagli
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Aug 16, 2019·Expert Review of Respiratory Medicine·David BennettPaola Rottoli
Jul 19, 2016·Current Opinion in Pulmonary Medicine·Alfonso CarleoPaola Rottoli
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Aug 6, 2020·Journal of Clinical Medicine·Valérie Besnard, Florence Jeny
Aug 18, 2020·American Journal of Respiratory Cell and Molecular Biology·Candace R GuerreroManeesh Bhargava
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Mar 12, 2021·Scientific Reports·Dariusz JastrzebskiDariusz Ziora
Aug 8, 2021·Diagnostics·Thomas El JammalPascal Sève
Jul 20, 2021·Journal of Breath Research·Yuqing TangChunlan Tang

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