PMID: 2500703Jun 1, 1989Paper

A functional study of purified CD4+ and CD8+ cells isolated from synovial fluid of patients with rheumatoid arthritis and other arthritides

Scandinavian Journal of Immunology
J HovdenesO J Mellbye

Abstract

The purpose of this investigation was to study purified synovial fluid (SF) CD4+ and CD8+ cells from patients with rheumatoid arthritis (RA) and other inflammatory joint diseases (non-RA) with respect to the proliferative response to mitogens and recombinant interleukin 2 (rIL-2). Highly purified cell subsets were isolated by an immunomagnetic technique, and spontaneous proliferation as well as proliferative reSponses to rIL-2 and a combination of phytohaemagglutinin (PHA) and phorbol myristate acetate (PMA) (to substitute for accessory cells) were measured. Some patients had SF CD4+ and/or CD8+ cells with moderately increased spontaneous proliferation, but only the CD4+ cells of the two patient groups differed significantly from the peripheral blood (PB) T-cell subsets of healthy individuals who served as controls. The response to rIL-2 was variable but generally low, although about 50% of the CD4+ and 20% of the SF CD8+ cells of both patient groups expressed the Tac antigen. The response to PHA/PMA was significantly lower for RA SF CD4+ cells than for non-RA SF CD4+ cells, which again was lower than for normal PB CD4+ cells. SF CD8+ response to PMA/PHA by both groups of patients was somewhat decreased, but not significantly l...Continue Reading

References

Sep 11, 1975·The New England Journal of Medicine·J A Van Boxel, S A Paget
Feb 1, 1986·The Journal of Experimental Medicine·M Gullberg, K A Smith
May 1, 1988·Scandinavian Journal of Immunology·T LeivestadE Thorsby
Jan 1, 1987·Scandinavian Journal of Immunology·T Egeland, H Lund
Sep 1, 1974·Arthritis and Rheumatism·K AhoA Tiilikainen
Apr 5, 1973·The New England Journal of Medicine·L SchlossteinC M Pearson
Nov 14, 1981·British Medical Journal·J C WoodrowG Zaphiropoulos

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Citations

Aug 1, 1996·Arthritis and Rheumatism·C Hernández-GarcíaJ A Jover
Apr 26, 2011·FEBS Letters·Saba Alzabin, Richard O Williams
Feb 1, 1990·Scandinavian Journal of Immunology·A J PotocnikR A Kroczek
Dec 1, 1990·Clinical and Experimental Immunology·A M MiltenburgF C Breedveld

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