Abstract
To examine rabbit cavernosal smooth muscle (CSM) relaxation to ATP, ADP and UTP in normal rabbits and in models of conditions that predispose to erectile dysfunction (ED), diabetes mellitus (DM; induced for 6 months) and bladder outlet obstruction (BOO, 6 weeks after surgery). Concentration-response curves (CRCs) were constructed to ATP, ADP and UTP on CSM from control rabbits in the absence and presence of antagonists. In addition, CRCs were constructed to ATP in CSM from rabbits with DM and BOO. ATP and UTP caused equipotent, dose-dependent relaxations of pre-contracted normal rabbit CSM; ADP was more potent. Relaxation was inhibited by Reactive Blue 2, but not by suramin, 8-p-sulfophenyltheophylline or L-N(G)-nitroarginine methyl ester. In rabbits with DM and those with partial BOO, ATP-mediated CSM relaxation was less than in control rabbits. Pharmacological profiling suggests that purine-induced CSM relaxation might be mediated by P2Y(1) and P2Y(4) receptors in the rabbit. In healthy rabbits, ATP released from nerves appears to produce relaxation of CSM via P2Y(4) receptors on smooth muscle, while ADP, acting on P2Y(1) receptors on endothelial cells, produces relaxation via nitric oxide. Alterations in CSM purinergic signa...Continue Reading
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Citations
Apr 3, 2013·Purinergic Signalling·Geoffrey Burnstock, Ivana Novak
Nov 26, 2013·Purinergic Signalling·Geoffrey Burnstock
Oct 30, 2013·The Journal of Sexual Medicine·Claire DoyleKeith D Thornbury
Nov 6, 2009·The Journal of Sexual Medicine·Prasad V PhatarpekarYang Xia
Feb 23, 2010·Biochemical Pharmacology·Mehdi GhasemiAli R Mani
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Jan 13, 2012·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Geoffrey Burnstock
May 20, 2015·Autonomic Neuroscience : Basic & Clinical·George I Gorodeski
Jun 20, 2012·International Journal of Andrology·V HupertanT Lebret
Jul 6, 2014·International Neurourology Journal·Junyang JungNa Young Jeong
Oct 11, 2017·Frontiers in Pharmacology·Geoffrey Burnstock
Dec 6, 2018·Brain and Neuroscience Advances·Geoffrey Burnstock