A functionalized TiO2 /Mg2 TiO4 nano-layer on biodegradable magnesium implant enables superior bone-implant integration and bacterial disinfection

Biomaterials
Zhengjie LinKelvin W K Yeung

Abstract

Rapid corrosion of biodegradable magnesium alloys under in vivo condition is a major concern for clinical applications. Inspired by the stability and biocompatibility of titanium oxide (TiO2) passive layer, a functionalized TiO2/Mg2TiO4 nano-layer has been constructed on the surface of WE43 magnesium implant by using plasma ion immersion implantation (PIII) technique. The customized nano-layer not only enhances corrosion resistance of Mg substrates significantly, but also elevates the osteoblastic differentiation capability in vitro due to the controlled release of magnesium ions. In the animal study, the increase of new bone formation adjacent to the PIII-treated magnesium substrate is 175% higher at post-operation 12 weeks, whereas the growth of new bone on titanium control and untreated magnesium substrate are only 97% and 29%, respectively. In addition, its Young's modulus can be restored to about 82% as compared with the surrounding matured bone. Furthermore, this specific TiO2/Mg2TiO4 layer even exhibits photoactive bacteria disinfection capability when irradiated by ultraviolet light which is attributed to the intracellular reactive oxygen species (ROS) production. With all these constructive observations, it is believed...Continue Reading

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Citations

Apr 9, 2020·Frontiers in Bioengineering and Biotechnology·Fengxuan HanBin Li
Jun 15, 2020·Colloids and Surfaces. B, Biointerfaces·Yunting GuoJianshe Lian
May 6, 2021·Advanced Healthcare Materials·Chang XieHongwei Ouyang
Jun 25, 2021·Advanced Science·Donghui WangXuanyong Liu
Aug 13, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xiangji LiuPeibiao Zhang
Sep 4, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Bingbing WangYong Huang
Dec 4, 2021·Nano-micro Letters·Lei YangYuanjin Zhao

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