PMID: 7538212Feb 9, 1995Paper

A functionally active presynaptic high-affinity kainate receptor in the rat hippocampal CA3 subregion

Neuroscience Letters
J O MalvaC M Carvalho

Abstract

We studied the modulation of the intracellular free calcium concentrations ([Ca2+]i) by kainate/AMPA receptor activation in synaptosomes isolated from whole rat hippocampus, or from its CA1, CA3 or dentate gyrus subregions. The receptor was activated either by 100 microM S-alpha-amino-3-hydroxy-5-methyl-4-isoxazolopropionic acid (AMPA) (EC50 = 26.6 +/- 4.9 microM) or by 100 microM kainate (EC50 = 0.81 +/- 0.1 microM), but the effects of these agonists were not additive. The response to either AMPA or kainate was competitively inhibited by 10 microM 6-cyano-7-nitroquinoxaline-2,3-dioxine. Higher [Ca2+]i responses to 100 microM AMPA or to 100 microM kainate were observed in the CA3 subregion (43.2 +/- 2.5 nM or 42.8 +/- 2.3 nM, respectively) than in the whole hippocampus (22.4 +/- 1.1 nM or 22.4 +/- 1.6, respectively), in the CA1 subregion (26.4 +/- 1.1 nM or 26.6 +/- 2.6 nM, respectively) or in dentate gyrus (24.6 +/- 1.4 nM or 21.5 +/- 1.0 nM, respectively). These results indicate that the CA3 subregion of the hippocampus is enriched in a presynaptic high-affinity kainate receptor which modulates the [Ca2+]i in nerve terminals.

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Citations

Jan 30, 2002·Neuroscience Research·Haruyuki Kamiya
Jun 28, 2000·Neuroscience·D A HenzeG Barrionuevo
Jul 3, 1999·Neuroscience·A ChararaY Smith
Dec 20, 2000·Neurotoxicology and Teratology·T A DoucetteR A Tasker
Apr 15, 1999·Annual Review of Neuroscience·A B MacDermottS A Siegelbaum
Jun 7, 2000·Proceedings of the National Academy of Sciences of the United States of America·I BureauC Mulle
Apr 27, 2004·The Journal of Physiology·Antonio Rodríguez-Moreno, Talvinder S Sihra
Jul 12, 2005·Neurochemistry International·P S PinheiroJ O Malva
Jun 27, 2012·Journal of Neurochemistry·Yuniesky Andrade-TalaveraAntonio Rodríguez-Moreno
Nov 6, 2007·Trends in Neurosciences·Antonio Rodríguez-Moreno, Talvinder S Sihra
Jun 28, 2001·Physiological Reviews·J LermaJ C López-García

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