A Functionally Conserved Gene Regulatory Network Module Governing Olfactory Neuron Diversity

PLoS Genetics
Qingyun LiPelin Cayirlioglu Volkan

Abstract

Sensory neuron diversity is required for organisms to decipher complex environmental cues. In Drosophila, the olfactory environment is detected by 50 different olfactory receptor neuron (ORN) classes that are clustered in combinations within distinct sensilla subtypes. Each sensilla subtype houses stereotypically clustered 1-4 ORN identities that arise through asymmetric divisions from a single multipotent sensory organ precursor (SOP). How each class of SOPs acquires a unique differentiation potential that accounts for ORN diversity is unknown. Previously, we reported a critical component of SOP diversification program, Rotund (Rn), increases ORN diversity by generating novel developmental trajectories from existing precursors within each independent sensilla type lineages. Here, we show that Rn, along with BarH1/H2 (Bar), Bric-à-brac (Bab), Apterous (Ap) and Dachshund (Dac), constitutes a transcription factor (TF) network that patterns the developing olfactory tissue. This network was previously shown to pattern the segmentation of the leg, which suggests that this network is functionally conserved. In antennal imaginal discs, precursors with diverse ORN differentiation potentials are selected from concentric rings defined by...Continue Reading

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Citations

Oct 30, 2016·Proceedings of the National Academy of Sciences of the United States of America·Fotini A KoutroumpaDavid G Heckel
Mar 31, 2017·Cellular and Molecular Life Sciences : CMLS·Yi-Wen HsiehChiou-Fen Chuang
Sep 15, 2018·Frontiers in Cellular Neuroscience·Carolina Gomez-DiazEsther Alcorta
Jan 4, 2019·Journal of Bioenergetics and Biomembranes·Eryn SlanksterDennis Mathew
Feb 9, 2019·Nature Communications·Phing Chian ChaiRichard Benton
Feb 9, 2020·The Journal of Experimental Biology·Hua YanClaude Desplan
Jun 11, 2021·Current Biology : CB·Alina VulpeKaren Menuz
May 26, 2021·ELife·Philipp SchlegelGregory S X E Jefferis

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Methods Mentioned

BETA
RNAseq
pull down
ChIP
immunoprecipitation
dissection
PCR

Software Mentioned

DAVID
DESeq2
DESeq2 R script
bwa

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