PMID: 3744363Aug 1, 1986Paper

A further improved method for identifying heteromorphism of acrocentric chromosomes

Human Genetics
T KameiN Niikawa

Abstract

An improved method for identifying an individual heteromorphic acrocentric chromosome, a high-resolution dual Q-R banding, is described. The acrocentrics of 550-850 band-stage prometaphase showed more distinct fluorescent heteromorphic patterns at their paracentromeric regions than those of 400 band-stage metaphase. In the two families studied, all four (two pairs of) parental prometaphase homologues in every kind of acrocentric except chromosome 22 were clearly distinguished from each other, leading to accurate determination of the parental origin of all the children's acrocentric chromosomes. The dual Q-R banding on metaphase plates could distinguish at most three of four such homologues of the parents in both families. Several possible applications of this method are discussed.

References

Oct 20, 1975·Humangenetik·N Niikawa, T Kajii
Jan 1, 1977·Cytogenetics and Cell Genetics·T Kajii, N Niikawa
May 1, 1984·Annals of Human Genetics·T HassoldJ A Yamane

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Citations

Dec 1, 1989·Jinrui idengaku zasshi. The Japanese journal of human genetics·N HaradaN Niikawa

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