A further study on antihypertensive action of beta-adrenoceptor blocking agents in conscious, renal hypertensive dogs

Experiments were carried out on 7 conscious, renal hypertensive dogs with 7 beta-adrenoceptor blocking agents (atenolol, bunitrolol, bunolol, carteolol, nadolol, sotalol and timolol). Three main conclusions may be made from this study: (1) the stronger the beta-adrenoceptor blocking activity the stronger the antihypertensive action; (2) for the antihypertensive action, very strong beta-adrenoceptor blocking activity was needed; (3) d-carteolol, unlike dl-carteolol, had no antihypertensive effect. Thus, the beta-adrenoceptor blocking action per se is a prerequisite for the antihypertensive effect of the beta-adrenoceptor blocking agents.