A G1-lineage H9N2 virus with oviduct tropism causes chronic pathological changes in the infundibulum and a long-lasting drop in egg production

Veterinary Research
Francesco BonfanteCalogero Terregino

Abstract

Since 1997, G1-lineage H9N2 avian influenza viruses have been circulating in Asia and later on in the Middle East, and they have been associated to mild respiratory disease, drops in egg production and moderate mortality in chickens, in particular in the presence of concurrent infections. In this study, we investigated the importance of the G1-lineage H9N2 A/chicken/Israel/1163/2011 virus as a primary pathogen in layers, analyzing its tropism and binding affinity for the oviduct tissues, and investigating the long-term impact on egg production. Besides causing a mild respiratory infection, the virus replicated in the oviduct of 60% of the hens causing different degrees of salpingitis throughout the organ, in particular at the level of the infundibulum, where the detection of the virus was associated with severe heterophilic infiltrate, and necrosis of the epithelium. Binding affinity assays confirmed that the infundibulum was the most receptive region of the oviduct. The drop in egg production was at its peek at 2 weeks post-infection (pi) (60% decrease) and continued up to 80 days pi (35% decrease). On day 80 pi, non-laying birds showed egg yolk peritonitis, and histopathological analyses described profound alteration of the i...Continue Reading

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Citations

Dec 25, 2019·Cold Spring Harbor Perspectives in Medicine·Silvia Carnaccini, Daniel R Perez
Jul 10, 2019·Viruses·T Homas P PeacockMunir Iqbal
Jul 7, 2020·EFSA Journal·UNKNOWN European Food Safety AuthorityFrancesca Baldinelli
Dec 20, 2018·EFSA Journal·UNKNOWN European Food Safety AuthorityFrancesca Baldinelli
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Sep 3, 2020·EFSA Journal·UNKNOWN European Food Safety AuthorityFrancesca Baldinelli
Sep 3, 2020·EFSA Journal·UNKNOWN European Food Safety AuthorityFrancesca Baldinelli
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Datasets Mentioned

BETA
JQ973659

Methods Mentioned

BETA
ELISA
sedation
PCR
PCRs

Software Mentioned

Rad
Bio
GraphPad Prism

Related Concepts