A GABAergic cell type in the lateral habenula links hypothalamic homeostatic and midbrain motivation circuits with sex steroid signaling

Translational Psychiatry
Limei ZhangLee E Eiden

Abstract

The lateral habenula (LHb) has a key role in integrating a variety of neural circuits associated with reward and aversive behaviors. There is limited information about how the different cell types and neuronal circuits within the LHb coordinate physiological and motivational states. Here, we report a cell type in the medial division of the LHb (LHbM) in male rats that is distinguished by: (1) a molecular signature for GABAergic neurotransmission (Slc32a1/VGAT) and estrogen receptor (Esr1/ERα) expression, at both mRNA and protein levels, as well as the mRNA for vesicular glutamate transporter Slc17a6/VGLUT2, which we term the GABAergic estrogen-receptive neuron (GERN); (2) its axonal projection patterns, identified by in vivo juxtacellular labeling, to both local LHb and to midbrain modulatory systems; and (3) its somatic expression of receptors for vasopressin, serotonin and dopamine, and mRNA for orexin receptor 2. This cell type is anatomically located to receive afferents from midbrain reward (dopamine and serotonin) and hypothalamic water and energy homeostasis (vasopressin and orexin) circuits. These afferents shared the expression of estrogen synthase (aromatase) and VGLUT2, both in their somata and axon terminals. We dem...Continue Reading

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Citations

May 3, 2018·Journal of Neurophysiology·S E MondelloC T Moritz
Mar 13, 2019·The European Journal of Neuroscience·Mauro CongiuSalvatore Lecca
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May 29, 2020·The European Journal of Neuroscience·Mahathi RamaswamySuresh Jesuthasan
Oct 28, 2019·Annals of the New York Academy of Sciences·Limei Zhang, Lee E Eiden
May 24, 2020·Scientific Reports·Jack F WebsterChristian Wozny
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Aug 19, 2020·Current Biology : CB·Jack F Webster, Christian Wozny
Apr 17, 2020·ACS Pharmacology & Translational Science·Lee E EidenLimei Zhang

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Methods Mentioned

BETA
hormone replacement therapy
confocal microcopy
testosterone replacement therapy

Software Mentioned

Neurobiotin

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