A game theory model for gut bacterial nutrient utilization strategies during human infancy

Proceedings. Biological Sciences
Inga Leena Angell, Knut Rudi

Abstract

Despite the fact that infant gut colonization patterns have been extensively studied, we have limited knowledge about the underlying ecological processes. This particularly relates to the ecological choice of nutrient utilization strategies. The aim of the current study was therefore to compare empirically determined nutrient utilization strategies with that expected from a combinatorial game theory model. Observational analyses for 100 mother-child pairs suggested mother-child transmission of specialists with the potential to use few nutrients. Generalists, on the other hand, with the potential to use many nutrients, peaked at three months of age for the children. The level of generalists was gradually replaced with specialists up to 12 months of age. Game theory simulation revealed a competitive advantage of generalists in an expanding population, while more specialized bacteria were favoured with the maturation of the population. This suggests that the observed increase in generalists in the three-month-old children could be due to an immature, expanding gut microbiota population while the increase of specialists at 12 months could be due to population maturation. The simulated and empirical data also correspond with respect...Continue Reading

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Citations

Nov 28, 2020·Analytical and Bioanalytical Chemistry·Fangchen LiuMingming Wu
Dec 23, 2020·Proceedings. Biological Sciences·James E McDonaldBritt Koskella
Jul 10, 2021·European Journal of Immunology·Timur Tuganbaev, Kenya Honda

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