A ganglioneuroma of the sigmoid colon presenting as leading point of intussusception in a child: a case report

Journal of Pediatric Surgery
Giampiero SoccorsoShawqui Nour

Abstract

We present a case of intestinal ganglioneuroma (GN) of the sigmoid colon in a 5-year-old girl, which caused intermittent colocolic intussusception. Ganglioneuromas are rare benign tumors of the autonomic nervous system composed of mature ganglion cells and satellite cells. Colonic GNs are uncommon. The unusual intramural proliferation of neural elements in this case resembled the diffuse intestinal ganglioneuromatosis, which is known to be associated with multiple endocrine neoplasia type 2B. However, the specific mutations of multiple endocrine neoplasia type 2B were not found by genetic sequencing. This is the first pediatric case described in the literature of a solitary polypoid GN presenting as a colocolic intussusception. We present a brief overview of intestinal ganglioneuromatous lesions and associated conditions.

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Citations

Jan 1, 2011·BMJ Case Reports·Zubair AHmadAsim Qureshi
May 25, 2013·Journal of Pediatric Surgery·Mika A B MatthewsGail E Besner
Jan 27, 2011·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·Marios LoukasRobert Jordan
Mar 28, 2013·Case Reports in Surgery·Anupam DasDheer Singh Kalwaniya
Dec 17, 2014·Journal of Endocrinological Investigation·C SpinelliS Strambi
Jul 15, 2015·Pediatric Gastroenterology, Hepatology & Nutrition·Hyung Min KeeIn Seok Lim
Nov 27, 2016·Journal of Gastrointestinal Cancer·Mohamed AbdelfatahGlenn Harvin
Apr 1, 2021·Italian Journal of Pediatrics·Angela MauroGiovanni Di Nardo

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