A gantry-based tri-modality system for bioluminescence tomography.

The Review of Scientific Instruments
Han YanGultekin Gulsen

Abstract

A gantry-based tri-modality system that combines bioluminescence (BLT), diffuse optical (DOT), and x-ray computed tomography (XCT) into the same setting is presented here. The purpose of this system is to perform bioluminescence tomography using a multi-modality imaging approach. As parts of this hybrid system, XCT and DOT provide anatomical information and background optical property maps. This structural and functional a priori information is used to guide and restrain bioluminescence reconstruction algorithm and ultimately improve the BLT results. The performance of the combined system is evaluated using multi-modality phantoms. In particular, a cylindrical heterogeneous multi-modality phantom that contains regions with higher optical absorption and x-ray attenuation is constructed. We showed that a 1.5 mm diameter bioluminescence inclusion can be localized accurately with the functional a priori information while its source strength can be recovered more accurately using both structural and the functional a priori information.

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Citations

May 27, 2014·Photonics·Xiaofeng Zhang
Oct 17, 2014·Optics Express·Hakan ErkolMehmet B Unlu
Jan 1, 2013·Measurement Science & Technology·James A GuggenheimHamid Dehghani

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Methods Mentioned

BETA
imaging technique
imaging techniques
x-ray CT
x-ray computed tomography
bioluminescence

Software Mentioned

Labview
DOT

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