PMID: 5912208Jun 1, 1966

A gastric phase of pancreatic secretion

The Journal of Physiology
E L BlairT Scratcherd


1. Extracts of antral mucosa increase the output of pancreatic amylase. They do not stimulate the resting pancreas of the anaesthetized cat to secrete juice, but have a slight ;secretin-like' effect on a pancreas already responding to endogenous or exogenous secretin.2. In animals with the vagus and splanchnic nerves cut instillation of meat extracts or acetylcholine into the antrum stimulates gastric acid and pancreatic amylase secretion. These responses can be prevented by injection of atropine or cocainization of the antral mucosa.3. In animals with the splanchnic nerves cut but the vagus nerves intact, distension of the body or antrum increases the output of amylase. After vagal section distension of the body has no effect on the pancreas, but the response to antral distension is still present.4. It is concluded that there is a gastric phase of pancreatic secretion which, in the cat, is almost entirely a stimulation of enzyme output. A vago-vagal reflex pathway is required for the pancreatic response to mechanical stimulation of the body of the stomach, and may be involved in the response to antral stimulation. Chemical and mechanical stimulation of the antrum produces a hormonally mediated increase in pancreatic enzyme sec...Continue Reading


Aug 1, 1990·Pflügers Archiv : European journal of physiology·E L Stuenkel, S R Hootman
Jan 1, 1988·Baillière's Clinical Gastroenterology·D Grundy
Aug 31, 1979·World Journal of Surgery·S J Konturek
Sep 20, 1979·World Journal of Surgery·H D BeckerA Schafmayer
Jul 25, 2003·Autonomic Neuroscience : Basic & Clinical·Naohiro FurukawaEmi Nakamura
Nov 1, 1974·American Journal of Surgery·A H McArdleA G Thompson
Apr 1, 1972·Gut·A A Harper
Apr 1, 1968·Gut·H SarlesC Figarella
Oct 1, 1990·European Journal of Clinical Investigation·R Ebert
May 3, 1969·The Medical Journal of Australia·A R Cooke

Related Concepts

Acetylcholine Sulfate (1: 1)
Felis catus
Cocaine Hydrochloride
Gastric Juice
Structure of Pyloric Gland
Nerve Conduction Function
Pancreatic Juice

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.